CD57

(redirected from Leu7)

CD57

a membrane protein present on natural killer cells, some T cells, a few B cells, and monocytes of unknown function; expressed in large granular lymphocyte leukemias.
Farlex Partner Medical Dictionary © Farlex 2012

CD57

A glucuronyltransferase encoded by B3GAT1 on chromosome 11q25 which is involved in the biosynthesis of the L2/HNK-1 carbohydrate epitope on glycoproteins, and which also plays a role in glycosaminoglycan biosynthesis.

Normal expression
NK cells, oligodendrocytes, Schwann cells, gastric chief cells, gut chromaffin cells, pancreatic islets, renal proximal tubules and loop of Henle, prostatic epithelium, adrenal medulla, epithelial cells of outer thymic cortex, and some fetal bronchial cells.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

CD57

A cell surface antigen expressed on many natural killer cells.
See: cluster of differentiation
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
Amino acid residues, that is, Arg117, His118, Val120, Arg121 and Arg3, Leu13, Gly1, Thr2, Leu123 and Leu16, Ser4 and Ser5, Pro119, Cys6, and Leu7 of TLP were found to involve in binding with membrane ergosterol through van der Waals interactions; however, Gln 139 amino residue interacts with the ergosterol through hydrogen bonding pattern as shown in Figure 7.
Therefore, only synaptophysin and chromogranin A are recommended for use in routine practice, and other neuroendocrine markers, such as CD56/NCAM1, Leu7, and neuron-specific enolase, are not recommended because of their low specificity.
The new analogue structure is similar to triptorelin with two extra chemical groups inserted between Leu7 and Arg8 in order to increase peptide hydrophobic properties (Figure 1).
Typical immunohistochemistry findings include positivity of the mesenchymal portion for vimentin, Leu7, and CD99 and positivity of the cartilaginous regions for S100 protein.