Lennox-Gastaut syndrome


Also found in: Acronyms, Wikipedia.

Len·nox-Gas·taut syn·drome

(len'ŏks gahs-tō),
a generalized myoclonic astatic epilepsy in children, with mental retardation, resulting from various cerebral afflictions such as perinatal hypoxia, cerebral hemorrhage, encephalitides, and maldevelopment or metabolic disorders of the brain; characterized by multiple seizure types (generalized tonic, atonic, myoclonic, tonic-clonic, and atypical absence) and background slowing and slow spike and wave pattern on EEG.
Synonym(s): Lennox syndrome

Lennox-Gastaut syndrome

Lennox syndrome Neurology A severe encephalopathic form of epilepsy that constitutes 5% of all childhood epilepsies Clinical Early onset of multiple types–eg, absence, atonic, and others of seizures, slow spike-wave EEG pattern, cerebral atrophy, and often progressive mental retardation; seizures are poorly controlled even with multiple anticonvulsants Prognosis For cognitive development, poor; felbamate may ↓ Sx. See Felbamate.

Len·nox-Gas·taut syn·drome

, Lennox syndrome (len'ŏks gahs-tō' sin'drōm)
A generalized myoclonic astatic epilepsy in children, with mental retardation, resulting from various cerebral afflictions such as perinatal hypoxia, cerebral hemorrhage, encephalitides, maldevelopment or metabolic disorders of the brain; characterized by multiple seizure types (generalized tonic, atonic, myoclonic, tonic-clonic, and atypical absence) and background slowing and slow spike and wave pattern on electroencephalogram; patients are usually mentally retarded or developmentally delayed.

Gastaut,

Henri, French biologist, 1915–.
Gastaut syndrome - juvenile hemiplegic epilepsy with ipsilateral signs.
Lennox-Gastaut syndrome - see under Lennox

Lennox,

William G., U.S. neurologist, 1884-1960.
Lennox-Gastaut syndrome - a generalized myoclonic astatic epilepsy in children, with mental retardation. Synonym(s): Lennox syndrome
Lennox syndrome - Synonym(s): Lennox-Gastaut syndrome
References in periodicals archive ?
Koszer conducted a retrospective chart review of 19 patients with Lennox-Gastaut syndrome (average age 34.5 years) who received levetiracetam as adjunctive therapy.
* The report reviews key players involved Lennox-Gastaut Syndrome therapeutics and enlists all their major and minor projects
A 12-week double-blind comparative study of rufinamide versus placebo as an adjunctive therapy to other antiepileptic drugs (AEDs) was conducted in 138 patients with Lennox-Gastaut syndrome (LGS) aged between 4 and 30 years old.
The agent received approval in the European Union in January 2007 and in the United States in November 2008 as an adjunctive therapy to other AEDs in the treatment of seizures associated with Lennox-Gastaut syndrome (LGS).
requested input on these options as well as Lennox-Gastaut syndrome, uncontrolled seizure disorders, seizure medications that have helped reduce or control seizures, and experiences with surgical procedures with either positive or negative results.
It also has been used in infantile spasms and Lennox-Gastaut syndrome. It may have adverse effects on concentration and attention and cause fatigue and nervousness, said Dr.
'We were excited in the second quarter to complete enrollment for Study 1601, our global Phase 3 trial of FINTEPLA for the treatment of seizures associated with Lennox-Gastaut syndrome (LGS),' continued Dr.
Zogenix announced that detailed results of the Phase 2, open-label study evaluating its investigational drug, ZX008, for the treatment of refractory patients with Lennox-Gastaut Syndrome, or LGS, were published in the September issue of Epilepsia.
Silver Spring, Maryland-based public health protection provider US FDA has approved Epidiolex (cannabidiol) oral solution for the treatment of seizures associated with two rare and severe forms of epilepsy, Lennox-Gastaut syndrome and Dravet syndrome, in patients two years of age and older, the agency said.
In three phase three trials, the marijuana-based drug was indicated to significantly decrease the frequency of seizures in patients with Lennox-Gastaut syndrome and Dravet syndrome when added to other antiepileptic therapies.
Lennox-Gastaut syndrome and Dandy-Walker malformation