Lennox-Gastaut syndrome


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Len·nox-Gas·taut syn·drome

(len'ŏks gahs-tō),
a generalized myoclonic astatic epilepsy in children, with mental retardation, resulting from various cerebral afflictions such as perinatal hypoxia, cerebral hemorrhage, encephalitides, and maldevelopment or metabolic disorders of the brain; characterized by multiple seizure types (generalized tonic, atonic, myoclonic, tonic-clonic, and atypical absence) and background slowing and slow spike and wave pattern on EEG.
Synonym(s): Lennox syndrome

Lennox-Gastaut syndrome

[len′oks-gästō′]
Etymology: William G. Lennox, American neurologist, 1884-1960; Henri Gastaut, French biologist, b. 1914
a condition in which a variety of generalized seizures, such as tonic, atonic, absence, tonic-clonic, akinetic, and myoclonic, begin to appear in the first 5 years of life. Seizures are often intractable and may require multiple antiepileptic medications. Mental retardation is often present. Among suggested causes are inherited metabolic abnormalities and perinatal or postnatal disorders. Also called Gastaut's disease.

Lennox-Gastaut syndrome

Lennox syndrome Neurology A severe encephalopathic form of epilepsy that constitutes 5% of all childhood epilepsies Clinical Early onset of multiple types–eg, absence, atonic, and others of seizures, slow spike-wave EEG pattern, cerebral atrophy, and often progressive mental retardation; seizures are poorly controlled even with multiple anticonvulsants Prognosis For cognitive development, poor; felbamate may ↓ Sx. See Felbamate.

Len·nox-Gas·taut syn·drome

, Lennox syndrome (len'ŏks gahs-tō' sin'drōm)
A generalized myoclonic astatic epilepsy in children, with mental retardation, resulting from various cerebral afflictions such as perinatal hypoxia, cerebral hemorrhage, encephalitides, maldevelopment or metabolic disorders of the brain; characterized by multiple seizure types (generalized tonic, atonic, myoclonic, tonic-clonic, and atypical absence) and background slowing and slow spike and wave pattern on electroencephalogram; patients are usually mentally retarded or developmentally delayed.

Gastaut,

Henri, French biologist, 1915–.
Gastaut syndrome - juvenile hemiplegic epilepsy with ipsilateral signs.
Lennox-Gastaut syndrome - see under Lennox

Lennox,

William G., U.S. neurologist, 1884-1960.
Lennox-Gastaut syndrome - a generalized myoclonic astatic epilepsy in children, with mental retardation. Synonym(s): Lennox syndrome
Lennox syndrome - Synonym(s): Lennox-Gastaut syndrome
References in periodicals archive ?
14] Efficacy in the treatment of Lennox-Gastaut syndrome and other difficult-to-treat refractory childhood epilepsies has been reported in open studies.
Because LGS is not a common seizure disorder, many families struggle to find local support, and some may never have had the opportunity to connect in person with another family coping with the condition," said Christina SanInocencio, president, Lennox-Gastaut Syndrome Foundation.
rufinamide) demonstrates favourable efficacy as adjunctive treatment for adults with Lennox-Gastaut syndrome.
Earlier, Banzel had secured FDA approval to treat seizures associated with Lennox-Gastaut Syndrome in children older than age 4.
Elizabeth suffers with a rare form of epilepsy called Lennox-Gastaut Syndrome, which maKes life very hard.
It is indicated for adjunctive therapy in partial seizures, generalized seizures of Lennox-Gastaut syndrome, and primary generalized tonic-clonic seizures in adults and pediatric patients (greater than or equal to 2 years) as well as for conversion to monotherapy in adults with partial seizures who are receiving treatment with carbamazepine, phenytoin, phenobarbital, primidone, or valproate.
Topiramate has been approved for treating partial-onset seizures, generalized tonic-clonic seizures, and seizures associated with Lennox-Gastaut syndrome.
An anticonvulsant for add-on therapy in people aged 2 and older with seizures related to Lennox-Gastaut syndrome, the third anticonvulsant approved for this devastating form of epilepsy Previously approved as adjunctive therapy for partial-onset seizures and primary, generalized tonic-clonic seizures in children and adults.
SAN DIEGO -- Data from a long-term, open-label extension study (OLE) evaluating ONFI (clobazam) Tablets CIV for the adjunctive treatment of drop seizures associated with Lennox-Gastaut syndrome (LGS) were presented as a late-breaking poster at the annual meeting of the American Epilepsy Society (AES).
XR is also approved as an adjunctive therapy in patients two years of age or older with POS, primary generalized tonic-clonic seizures, or seizures associated with Lennox-Gastaut syndrome.