Leishmania donovani

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Related to Leishmania donovani: leishmaniasis, Leishmania tropica

Leish·man·i·a don·o·va'n·i

a species that is the causal agent of visceral leishmaniasis in Mediterranean and adjacent countries, the south central section of western Asia, eastern India, northern China, Kenya, Ethiopia, and the Sudan; also found in Brazil, Argentina, Colombia, and Venezuela; in the Old World, it is transmitted by various species of Phlebotomus; New World vectors are species of Lutzomyia; dogs and other carnivores are known as reservoir hosts in some areas. The intracellular amastigote form multiplies in macrophages and produces a reticuloendothelial hyperplasia grossly affecting the spleen and liver, with other lymphoid tissues being involved as well, resulting in severe hepatosplenomegaly, which usually is fatal if untreated.

Leishmania donovani

The causative agent of kala azar (visceral leishmaniasis).
See also: Leishmania
References in periodicals archive ?
Therapeutic use of recombinant cytokine(s) inhibit parasitic growth in visceral organs of Leishmania donovani infected mice
A cross-sectional study design was carried out to determine the seroprevalence of asymptomatic Leishmania donovani among laborers and to assess associated risk factors in agricultural camps of West Armachiho district.
Caption: Figure 3: Fluorescence of Leishmania donovani promastigotes incubated with Bodi Fluor 488-labeled PMM-Tat conjugate (9 [micro]M, 4h, 26[degrees] C) and stained with DAPI (5 [micro]g/mL) immediately before observation, unfixed.
Martinkovic et al., "Heterogeneity of Leishmania donovani parasites complicates diagnosis of visceral leishmaniasis: comparison of different serological tests in three endemic regions," PLoS ONE, vol.
Ali, "Gp63 in stable cationic liposomes confers sustained vaccine immunity to susceptible BALB/c mice infected with Leishmania donovani," Infection and Immunity, vol.
Loiseau, "In vitro antileishmanial properties of new flavonoids against Leishmania donovani," Biomedicine & Preventive Nutrition, vol.
Breard, "Miltefosine induces apoptosis-like death in Leishmania donovani promastigotes," Antimicrobial Agents and Chemotherapy, vol.
Gedamu, "Immunogenicity of Leishmania donovani iron superoxide dismutase B1 and peroxidoxin 4 in BALB/c mice: the contribution of Toll-like receptor agonists as adjuvant," Experimental Parasitology emphasizes, vol.
For example, the measles P protein has been shown to up-regulate the expression of A20 as a means of dampening the innate immune response, and a group working in India reported that the protozoan parasite Leishmania donovani has evolved a mechanism for modulating A20 activity as a means of facilitating intracellular survival.
Leishmania donovani develops resistance to drug combinations.
Miltefosine induces apoptosis in arsenite-resistant Leishmania donovani promastigotes trough mitochondrial dysfunction.

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