Leishmania donovani

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Related to Leishmania donovani: leishmaniasis, Leishmania tropica

Leish·man·i·a don·o·va'n·i

a species that is the causal agent of visceral leishmaniasis in Mediterranean and adjacent countries, the south central section of western Asia, eastern India, northern China, Kenya, Ethiopia, and the Sudan; also found in Brazil, Argentina, Colombia, and Venezuela; in the Old World, it is transmitted by various species of Phlebotomus; New World vectors are species of Lutzomyia; dogs and other carnivores are known as reservoir hosts in some areas. The intracellular amastigote form multiplies in macrophages and produces a reticuloendothelial hyperplasia grossly affecting the spleen and liver, with other lymphoid tissues being involved as well, resulting in severe hepatosplenomegaly, which usually is fatal if untreated.
Farlex Partner Medical Dictionary © Farlex 2012

Leishmania donovani

The causative agent of kala azar (visceral leishmaniasis).
See also: Leishmania
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
Therapeutic use of recombinant cytokine(s) inhibit parasitic growth in visceral organs of Leishmania donovani infected mice
A cross-sectional study design was carried out to determine the seroprevalence of asymptomatic Leishmania donovani among laborers and to assess associated risk factors in agricultural camps of West Armachiho district.
Caption: Figure 3: Fluorescence of Leishmania donovani promastigotes incubated with Bodi Fluor 488-labeled PMM-Tat conjugate (9 [micro]M, 4h, 26[degrees] C) and stained with DAPI (5 [micro]g/mL) immediately before observation, unfixed.
Martinkovic et al., "Heterogeneity of Leishmania donovani parasites complicates diagnosis of visceral leishmaniasis: comparison of different serological tests in three endemic regions," PLoS ONE, vol.
Ali, "Gp63 in stable cationic liposomes confers sustained vaccine immunity to susceptible BALB/c mice infected with Leishmania donovani," Infection and Immunity, vol.
Loiseau, "In vitro antileishmanial properties of new flavonoids against Leishmania donovani," Biomedicine & Preventive Nutrition, vol.
Breard, "Miltefosine induces apoptosis-like death in Leishmania donovani promastigotes," Antimicrobial Agents and Chemotherapy, vol.
Gedamu, "Immunogenicity of Leishmania donovani iron superoxide dismutase B1 and peroxidoxin 4 in BALB/c mice: the contribution of Toll-like receptor agonists as adjuvant," Experimental Parasitology emphasizes, vol.
For example, the measles P protein has been shown to up-regulate the expression of A20 as a means of dampening the innate immune response, and a group working in India reported that the protozoan parasite Leishmania donovani has evolved a mechanism for modulating A20 activity as a means of facilitating intracellular survival.
Leishmania donovani develops resistance to drug combinations.
Miltefosine induces apoptosis in arsenite-resistant Leishmania donovani promastigotes trough mitochondrial dysfunction.

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