Leishmania donovani

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Related to Leishmania donovani: leishmaniasis, Leishmania tropica

Leish·man·i·a don·o·va'n·i

a species that is the causal agent of visceral leishmaniasis in Mediterranean and adjacent countries, the south central section of western Asia, eastern India, northern China, Kenya, Ethiopia, and the Sudan; also found in Brazil, Argentina, Colombia, and Venezuela; in the Old World, it is transmitted by various species of Phlebotomus; New World vectors are species of Lutzomyia; dogs and other carnivores are known as reservoir hosts in some areas. The intracellular amastigote form multiplies in macrophages and produces a reticuloendothelial hyperplasia grossly affecting the spleen and liver, with other lymphoid tissues being involved as well, resulting in severe hepatosplenomegaly, which usually is fatal if untreated.

Leishmania donovani

The causative agent of kala azar (visceral leishmaniasis).
See also: Leishmania


a genus of protozoan parasites transmitted by sandflies, which also act as intermediate hosts.

Leishmania adleri
found in lizards and other mammals.
Leishmania aethiopica
reservoir hosts are hyraxes.
Leishmania brasiliensis brasiliensis
reservoir hosts are forest rodents. Causes mucocutaneous leishmaniasis in humans.
Leishmania brasiliensis guyanensis
dogs are infected; in humans the disease is the cutaneous form in most cases.
Leishmania brasiliensis panamensis
reservoirs are sloths, kinkajous and many other forest animals.
Leishmania chagasi
causes visceral leishmaniasis in humans and dogs.
Leishmania donovani
causes visceral leishmaniasis in humans and in carnivores.
Leishmania enriettii
causes cutaneous leishmaniasis in guinea pigs.
Leishmania infantum
causes visceral leishmaniasis in dogs and other carnivores. In humans it is children who are most commonly affected.
Leishmania major
dogs and bush mammals are reservoir hosts. In humans this is the cause of oriental sore, the important cutaneous form of the disease.
Leishmania mexicana amazonensis
causes cutaneous leishmaniasis in humans. Rodents and bush animals are reservoir hosts.
Leishmania mexicana mexicana
reservoir hosts are rodents; causes cutaneous leishmaniasis in humans.
Leishmania mexicana pifanoi
causes chronic cutaneous leishmaniasis in humans.
Leishmania peruviana
causes cutaneous leishmaniasis in humans; probably infests dogs.
Leishmania tropica
causes cutaneous leishmaniasis in humans and dogs.
References in periodicals archive ?
Nested PCR assay for detection of Leishmania donovani in slit aspirates from post-kala-azar dermal leishmaniasis lesions.
Regional differences in the cellular immune response to experimental cutaneous or visceral infection with Leishmania donovani.
Growth of Leishmania donovani amastigotes in the continuous human macrophages cell line U937: Studies on drug efficacy and metabolism.
Inhibition of Leishmania donovani promastigote internalization into murine macrophages by chemically defined parasite glycoconjugate.
Bone marrow aspirates were taken for Leishmania donovani bodies (LD bodies) and evaluation of the hematological abnormalities.
The activity of plumbagin and other electron carriers against Leishmania donovani and Leishmania mexicana amazonensis.
dagger])([dagger]) Antibodies probably correspond to contact with Leishmania donovani.
Visceral leishmaniasis (VL) or kala-azar, caused by Leishmania donovani, L.
Kala azar caused by Leishmania donovani and malaria due to P falciparum and Plasmodium vivax are endemic in the Southern Terai (plain areas) of Nepal.
The HESKA Canine Leishmania Antibody Test is an enzyme-linked immunosorbent assay (ELISA) which utilizes a recombinant antigen, K39, specific for the Leishmania donovani complex, to detect circulating antibodies in the serum of dogs with this debilitating disease.
Under the agreement, scientists in institutes affiliated with DNDi will test at least 150,000 compounds in the Pfizer library against Trypanosoma brucei, Leishmania donovani and Trypanosoma cruzi, the parasites that cause HAT, VL and Chagas Disease, respectively.

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