Leishmania donovani

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Related to Leishmania donovani: leishmaniasis, Leishmania tropica

Leish·man·i·a don·o·va'n·i

a species that is the causal agent of visceral leishmaniasis in Mediterranean and adjacent countries, the south central section of western Asia, eastern India, northern China, Kenya, Ethiopia, and the Sudan; also found in Brazil, Argentina, Colombia, and Venezuela; in the Old World, it is transmitted by various species of Phlebotomus; New World vectors are species of Lutzomyia; dogs and other carnivores are known as reservoir hosts in some areas. The intracellular amastigote form multiplies in macrophages and produces a reticuloendothelial hyperplasia grossly affecting the spleen and liver, with other lymphoid tissues being involved as well, resulting in severe hepatosplenomegaly, which usually is fatal if untreated.

Leishmania donovani

The causative agent of kala azar (visceral leishmaniasis).
See also: Leishmania


a genus of protozoan parasites transmitted by sandflies, which also act as intermediate hosts.

Leishmania adleri
found in lizards and other mammals.
Leishmania aethiopica
reservoir hosts are hyraxes.
Leishmania brasiliensis brasiliensis
reservoir hosts are forest rodents. Causes mucocutaneous leishmaniasis in humans.
Leishmania brasiliensis guyanensis
dogs are infected; in humans the disease is the cutaneous form in most cases.
Leishmania brasiliensis panamensis
reservoirs are sloths, kinkajous and many other forest animals.
Leishmania chagasi
causes visceral leishmaniasis in humans and dogs.
Leishmania donovani
causes visceral leishmaniasis in humans and in carnivores.
Leishmania enriettii
causes cutaneous leishmaniasis in guinea pigs.
Leishmania infantum
causes visceral leishmaniasis in dogs and other carnivores. In humans it is children who are most commonly affected.
Leishmania major
dogs and bush mammals are reservoir hosts. In humans this is the cause of oriental sore, the important cutaneous form of the disease.
Leishmania mexicana amazonensis
causes cutaneous leishmaniasis in humans. Rodents and bush animals are reservoir hosts.
Leishmania mexicana mexicana
reservoir hosts are rodents; causes cutaneous leishmaniasis in humans.
Leishmania mexicana pifanoi
causes chronic cutaneous leishmaniasis in humans.
Leishmania peruviana
causes cutaneous leishmaniasis in humans; probably infests dogs.
Leishmania tropica
causes cutaneous leishmaniasis in humans and dogs.
References in periodicals archive ?
Immunization with A2 protein results in a mixed Th1/Th2 and a humoral response which protects mice against Leishmania donovani infections.
Kinetic characterization of inosine monophosphate dehydrogenase of Leishmania donovani.
Visceral leishmaniasis or kala-azar caused by Leishmania donovani is a well-known endemic disease in the eastern part of India.
Leishmania donovani Ross, 1903 y Leishmania infantum Nicolle, 1908 son los agentes etiologicos de la leishmaniasis visceral humana [1, 2, 3].
Stage-specific activity of pentavalent antimony against Leishmania donovani axenic amastigotes.
tarentolae (5, 10), Leishmania donovani (11), Trypanosoma brucei (5, 17-19) y Trypanosoma cruzi (20) y, secuencias parciales de los maxicirculos de Leishmania major (21), Leishmania amazonensis (22), Crithidia fasciculata (23, 24) y Phytomonas serpens (25, 26).
The visceral strain, most commonly caused by leishmania donovani, leishmania infantum and leishmania chagasi, strikes its victimsAAE liver, spleen and bone marrow, and is deadly if untreated.
Se ha propuesto el uso de formas amastigotas de Leishmania donovani, como antigeno, aumentando significativamente la sensibilidad, sin perder la especificidad de la prueba, aspectos que han permitido sugerirla para el diagnostico precoz de animales asintomaticos y oligosintomaticos, y para realizar el monitoreo de la evaluacion clinica de animales tratados (12, 17).
The Leishmania donovani lipophosphoglycan T lymphocyte reactive component is a tightly associated protein complex.
Visceral leishmaniasis (VL) is caused by the parasites of Leishmania donovani and is transmitted by the bite of a Phlebotomus fly.

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