Leishman-Donovan bodies


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Leishman-Donovan bodies

(lesh'man-don-a-van)
[Sir William Boog Leishman, Brit. medical officer, 1865–1926; Charles Donovan, Brit. bacteriologist, 1863–1951]
Nonflagellated trypanosomes found within the cytoplasm of cells infected by Leishmania donovani, the pathogen that causes visceral Leishmaniasis.
Synonym: amastigote

Leishman-Donovan bodies

The form in which Leishmania parasites appear in MACROPHAGE cells in LEISHMANIASIS. They appear as oval, nucleated, non-flagellated structures in the CYTOPLASM of the MACROPHAGES. Also known as amastigotes . (Major-General Sir William Boog Leishman, 1865–1926, English Army pathologist, and Lt Col Charles Donovan, 1863–1951, Irish physician).

Leishman-Donovan bodies

round or oval bodies found in reticuloendothelial cells, especially those of the spleen and liver, in visceral leishmaniasis; they are amastigote intracellular stages of Leishmania donovani. The term is also used to designate similar forms of L. tropica found in macrophages in lesions of cutaneous leishmaniasis.
References in periodicals archive ?
Cytologic findings consisted of granuloma, macrophages loaded with Leishman-Donovan bodies (Figure 2, A), multinucleated giant cells (Figure 2, B), binucleated-histiocyte (Reed-Sternberg-like) cells loaded with Leishman-Donovan bodies, free Leishman-Donovan bodies, acute and chronic inflammatory cells, atypical organisms, histiocytes, plasma cells and mast cells (Figure 2, C), Leishman-Donovan bodies in the vicinity of respiratory epithelium in nasal smears, and atypical intracytoplasmic Leishman-Donovan bodies with ballooning changes.
However, after retrospective review of these sections, Leishman-Donovan bodies were detected in 3 of them.
of Cases Free Leishman-Donovan bodies 9 Histiocytes 9 Granuloma 7 Acute and chronic inflammatory cells 6 Multinucleated giant cells 5 Mast cells 6 Binucleated histiocytes (Reed-Sternberg-like cells) 6 Plasma cells 11 Atypical organisms 1 Intrahistiocytic Leishman-Donovan bodies 9 Table 2.