Leishman-Donovan bodies


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Leishman-Donovan bodies

(lesh'man-don-a-van)
[Sir William Boog Leishman, Brit. medical officer, 1865–1926; Charles Donovan, Brit. bacteriologist, 1863–1951]
Nonflagellated trypanosomes found within the cytoplasm of cells infected by Leishmania donovani, the pathogen that causes visceral Leishmaniasis.
Synonym: amastigote

Leishman-Donovan bodies

The form in which Leishmania parasites appear in MACROPHAGE cells in LEISHMANIASIS. They appear as oval, nucleated, non-flagellated structures in the CYTOPLASM of the MACROPHAGES. Also known as amastigotes . (Major-General Sir William Boog Leishman, 1865–1926, English Army pathologist, and Lt Col Charles Donovan, 1863–1951, Irish physician).
References in periodicals archive ?
Caption: Figure 2: Presence of (a) intracellular and (b) extracellular Leishman-Donovan bodies. Giemsa staining, magnification = 1000 x.
However, after retrospective review of these sections, Leishman-Donovan bodies were detected in 3 of them.
Infected macrophages measure 20-30 m across whereas amastigotes (known as Leishman-Donovan bodies) are round to oval structures measuring only 2-5m.
Granuloma formation may result from simple lipids in some cases (cholesterol granuloma).13 Apart from infectious agents such as Leishman-Donovan bodies and fungi, dead hair and myriad of foreign bodies may result in granuloma formation.