Leigh's disease

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Leigh’s disease

A rare autosomal-recessive mitochondrial disease of neonatal onset
Clinical findings Progressive loss of motor and verbal skills, swallowing and feeding difficulties, hypotonia, hyporeflexia, weakness, ataxia, peripheral neuropathy, external ophthalmoplegia, impaired hearing and vision, seizures, convulsions.

Molecular medicine
Caused by mutations in mitochondrial DNA, SURF1 or in COX assembly factors.

Usually fatal by age 2.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

Leigh's disease

Subacute necrotizing encephalopathy A mitochondrial disease of infants Clinical Progressive loss of motor and verbal skills Prognosis Usually fatal by age 2. See Mitochondrial disease.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
He has served on the Board for Brillo Soccer Ministry, on the Board of National Leigh's Disease Foundation, as President of the Board of the Mississippi Children's Legal Clinic, on the Mississippi College School of Business Administration Alumni Advisory Board and on the Mississippi College Child Advocacy Program Advisory Board.
The six-year-old is battling Leigh's disease, a rare inherited neurometabolic disorder that affects the central nervous system.
Leigh's disease 13 MLD 4 Wilson's disease 2 Gangliosidosis 2 PKAN (NBIA Type 1) 2 Canavan's disease 1 Alexander's disease 1 Glutaric aciduria 1 The criterion of image interpretation was the image based classification, which grossly divides these disorders on the pattern of involvement of gray and white matter.
She has Leigh's disease, a condition of the central nervous system.
Though he suffers from Leigh's disease, "he has not let it stop him from enjoying fun with the family, waiting on customers at Bolton Orchards, dancing with the Irish rhythm dancers or serving as an altar boy at St.
Conditions include Leigh's disease, progressive infantile poliodystrophy and Barth syndrome.
Their son Edward, who suffered from Leigh's disease, became the oldest person in the world to survive the condition before he died at the age of 21.
An NHS England spokesman said the SDR would not typically be considered as a treatment for Leigh's Disease.
Members of the FDA Cellular, Tissue, and Gene Therapies Advisory Committee mentioned two mitochondrial diseases in particular, Leigh's disease and MELAS (mitochondrial encephalomyopathy, lactic acidosis, and strokelike episodes), that could be included in initial clinical trials evaluating the safety and efficacy of what the FDA refers to as "mitochondrial manipulation technologies."
"Now the only thing we can do is help raise awareness of Leigh's Disease." We wanted to what wrong' SHELLEY " Elle-Louise was only two when she began having problems with her mobility and speech.
One of the cloned stem cell lines was created from cells from a child with Leigh's disease, a rare and severe genetic disorder.
On the other hand, putaminal changes may also be seen in Wilson's disease, Leigh's disease, Kearns-Sayre syndrome, carbon mono-oxide inhalation, hypoxic-ischaemic injury, trichloroethane poisoning and acute cyanide intoxication.6