Legionnaire's disease


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Legionnaire's disease

Legionella pneumonia Infectious disease A lung infection caused by Legionella pneumophila, which is either sporadic or epidemic with a mortality of up to 15%; depending on the population, Legionella spp cause 1–27% of CAPs; ♂:♀ ratio, 3:1 Epidemiology Most
L pneumophila infections are associated with buildings and ventilation systems; most epidemics occur during the summer with 0.5 to 5% attack rates; the only documented mode of spead is by air Risk factors Cigarettes, alcohol, renal transplant, ↑ age Clinical 2-10 day incubation, followed by an abrupt malaise, headache, myalgia, a dry, initially non-productive, later productive, cough, hemoptysis; fever to 40ºC, rigors often associated with bradycardia; less commonly, nausea, diarrhea, delirium, septicemia, abscesses, acute myocarditis, pericarditis, rhabdomyolysis DiffDx Sporadic LD mimics myoplasma pneumonia, Q fever, tularemia, plague, psittacosis, influenza and other viral pneumonias CXR Patchy, segmental, or lobar, often bilateral, alveolar infiltrates, often progressing to nodule Lab ↓ Na+, ↓ PO4–, ↑ liver enzymes, proteinuria, microscopic hematuria, relative leukocytosis, ↑ ESR, hyponatremia, ↑ ALT,
↑ AST, ↑ BR, azotemia Complications Empyema, shock, DIC, renal failure, neurologic sequelae, peripheral neuropathy Management Erythromycin, T-S, penicillin Prognosis 15-20% death w/o therapy; up to 50% death in immunocompromised Pts Poor prognostic features Tachycardia, tachypnea, WBCs
≥ 14,000/mm3, ↑ BUN, ↑ creatinine, hyponatremia, hypoxia, leukopenia, bilateral infiltrates on CXR Prevention Chlorination; UV irradiation of water supplies. See Community-acquired pneumonia, Legionella pneumophila. Cf Pontiac disease.

Legionnaire's disease

A lung disease caused by a bacterium.
Mentioned in: Erythromycins
References in periodicals archive ?
Professor Phin continued: "Health professionals should also remember to consider Legionnaire's disease as a possible diagnosis in individuals over the age of 50 with underlying health conditions and presenting with pneumonia-like symptoms, particularly if they are returning holidaymakers.
Miami-Dade health officials have issued an advisory for those who have recently stayed at the property to contact the department as well as their own personal physicians, especially if they have symptoms of Legionnaire's Disease.
No new cases of legionnaire's disease have been confirmed and the total remains at 28.
Legionnaire's Disease is often associated with hospitals because of their complicated plumbing systems which contain dead-ends where the bug can develop.
Legionnaire's Disease is monitored by the Communicable Disease Surveillance Centre in London, which registered three cases of the pneumonia-like illness among guests in July, November and earlier this month.
Legionnaire's disease is an infection that causes pneumonia and is treated with antibiotics.
We do not expect new people to develop legionnaire's disease.
A PENSIONER died after contracting Legionnaire's disease in a holiday swimming pool.
Coroner Nicholas Rheinberg said Legionnaire's disease was not considered a natural cause of death, so he had to record a verdict of accidental death.
HEALTH experts have launched an investigation after a train driver was admitted to hospital with suspected legionnaire's disease, it emerged today.
While the organism physically resembles that causing Legionnaire's disease in humans, Wells says that genetically it bears no resemblance to any known bacteria.