silibinin

(redirected from Legalon)

silibinin

One of two major constituents of silymarin (silibinins A and B), the main extract of milk thistle (Silybum marianum seeds), which have hepatoprotective effects (e.g., against Amanita phalloides (deathcap mushroom) poisoning) and anti-cancer activity (in animal models) against prostate adenocarcinoma, breast carcinoma cells, cervical carcinoma cells, colon cancer and both small and non-small lung carcinomas. It may also be useful for cirrhosis and type-2 diabetes.
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Silibinin-C-2'3-dihydrogen succinate, disodium salt (Legalon SIL) was a generous gift from MEDA Pharma GmbH & Co.
In addition, silymarin-type drugs like legalon have been used for the treatment of acute hepatitis and nonalcoholic fatty liver disease in patients (El-Kamary et al.
A number of clinical trials have used a capsule (Legalon) that has been standardised equivalent to 140mg of silymarin.
The intervention consisted of three times daily ingestion of either a standard recommended dose of 140 mg of silymarin (Legalon, MADAUS GmbH, Cologne, Germany), or a vitamin placebo for four weeks with an additional four-week follow-up.
First, 16 patients received 10 mg/kg/day SIL IV (Legalon Sil; Madaus, Koln, Germany) for 7 days.
Protective effect of Legalon in workers exposed to organic solvents.
The intervention consisted of three times daily ingestion of either a standard recommended dose of 140 mg of silymarin (Legalon [R], MADAUS GmbH, Cologne, Germany), or a vitamin placebo for four weeks with an additional four-week follow-up.