OLR1

(redirected from Lectin-like oxidized LDL receptor 1)

OLR1

A gene on chromosome 12p13.2-p12.3 that encodes a C-type lectin domain receptor which mediates the recognition, internalisation and degradation of oxidatively modified low-density lipoprotein (oxLDL) by vascular endothelial cells. It is also a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria, as well as for HSP70 protein, which is involved in antigen cross-presentation to naïve T-cells. OLR1 is also involved in inflammation, acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
Sawamura, "Lectin-like oxidized LDL receptor 1 is involved in CRP-mediated complement activation," Clinical Chemistry, vol.
[2] Nonstandard abbreviations: CRP, C-reactive protein; eNOS, endothelial nitric oxide synthase; EMP, endothelial microparticle; CEC, circulating endothelial cell; LPS, lipopolysaccharide; TLR4, Toll-like receptor 4; siRNA, small interfering RNA; HAEC, human aortic endothelial cell; BH4, tetrahydrobiopterin; DETA, diethylenetriamine; LOX-1, lectin-like oxidized LDL receptor 1; HuSA, human serum albumin; ACS, acute coronary syndrome.
Recently, we showed that CRP bound to CHO cells (hLOX-1-CHO) expressing human lectin-like oxidized LDL receptor 1 (LOX-1), and that CRP bound to recombinant human LOX-1 in a cell-free system (19, 20).
[3] Nonstandard abbreviations: MI, myocardial infarction; oxLDL, oxidized LDL LOX-1, lectin-like oxidized LDL receptor 1; EC, endothelial cell; hsCRP, high-sensitivity C-reactive protein; sLOX-1, soluble LOX-1; LAB, ligand-containing apoB.
Lectin-like oxidized LDL receptor 1 (LOX-1) is the receptor for oxidized LDL identified in endothelial cells (9, 10).