OLR1

(redirected from Lectin-like oxidized LDL receptor 1)

OLR1

A gene on chromosome 12p13.2-p12.3 that encodes a C-type lectin domain receptor which mediates the recognition, internalisation and degradation of oxidatively modified low-density lipoprotein (oxLDL) by vascular endothelial cells. It is also a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria, as well as for HSP70 protein, which is involved in antigen cross-presentation to naïve T-cells. OLR1 is also involved in inflammation, acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation.
References in periodicals archive ?
Finally, because data suggest that CRP binds to lectin-like oxidized LDL receptor 1 (LOX-1) (28), we examined the effect of LOX-1 siRNA on CRP's effects on EMPs and CECs.
Lectin-like oxidized LDL receptor 1 is involved in CRP-mediated complement activation.
Recently, we showed that CRP bound to CHO cells (hLOX-1-CHO) expressing human lectin-like oxidized LDL receptor 1 (LOX-1), and that CRP bound to recombinant human LOX-1 in a cell-free system (19, 20).
A major advance in this area came with the identification of the lectin-like oxidized LDL receptor 1 (LOX-1) that, upon activation by ox-LDL binding, induces multiple proatherosclerotic responses in endothelial cells (ECs) as well as smooth muscle cells and macrophages, including production of reactive oxygen species, release of matrix-degrading metalloproteinases, recruitment of leukocytes (increasing chemoattractant cytokines and adhesion molecule expression), reduced levels of endothelial nitric oxide synthase, and more apoptosis (4, 5).