lecithin-cholesterol acyltransferase

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lec·i·thin-cho·les·ter·ol ac·yl·trans·fer·ase (LCAT),

(les'i-thin-kō-les'tĕr-ōl as'ĭl-trans'fĕr-ās),
An enzyme that reversibly transfers an acyl residue from a lecithin to cholesterol, forming a 1-acylglycerophosphocholine (a lysolecithin) and a cholesteryl ester; a deficiency of this enzyme leads to accumulation of unesterified cholesterol in plasma resulting in anemia, proteinuria, renal failure, and corneal opacities; LCAT is also low in people with fish eye disease.
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References in periodicals archive ?
(6-8) The LXR-mediated genes include apo A1, lecithin-cholesterol acyltransferase (LCAT), cholesteryl ester transfer protein (CETP), and SRB1, which are all involved in reverse cholesterol transport.
By sequencing 3 genes known to be key for the metabolism of HDL cholesterol [ATP-binding cassette, sub-family A (ABC1), member 1 (ABCA1), apolipoprotein A-I (APOA1), and lecithin-cholesterol acyltransferase (LCAT)] in DHS individuals with extremely low and high HDL concentrations, Hobbs and Victor found that the number of mutations was 5 times higher in the low-HDL group than in the high-HDL group.
[2] Human genes: PCSK9, proprotein convertase subtilisin/kexin type 9; ABCA1, ATP-binding cassette, sub-family A (ABC1), member 1; APOA1, apolipoprotein A-I; LCAT, lecithin-cholesterol acyltransferase.
Regulation of the concentration of pre-beta high-density lipoprotein in normal plasma by cell membranes and lecithin-cholesterol acyltransferase activity.
(176.) Bolin DJ, Jonas A Sphingomyelin inhibits the lecithin-cholesterol acyltransferase reaction with reconstituted high density lipoproteins by decreasing enzyme binding.
LpX is also seen in lecithin-cholesterol acyltransferase deficiency and may contribute to nephropathy related to lecithin-cholesterol acyltransferase deficiency (4).
A novel in vivo lecithin-cholesterol acyltransferase (LCAT)deficient mouse expressing predominantly LpX is associated with spontaneous glomerulopathy.
LPC is a relevant component of human plasma originating from lecithin-cholesterol acyltransferase, hepatic secretion (4, 5), or action of phospholipase [A.sub.2] (6).
Abnormal plasma lipoproteins and lecithin-cholesterol acyltransferase deficiency in alcoholic liver disease.