lecithin-cholesterol acyltransferase

(redirected from Lecithin cholesterol acyltransferase)

lec·i·thin-cho·les·ter·ol ac·yl·trans·fer·ase (LCAT),

(les'i-thin-kō-les'tĕr-ōl as'ĭl-trans'fĕr-ās),
An enzyme that reversibly transfers an acyl residue from a lecithin to cholesterol, forming a 1-acylglycerophosphocholine (a lysolecithin) and a cholesteryl ester; a deficiency of this enzyme leads to accumulation of unesterified cholesterol in plasma resulting in anemia, proteinuria, renal failure, and corneal opacities; LCAT is also low in people with fish eye disease.
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References in periodicals archive ?
Association of lecithin cholesterol acyltransferase rs5923 polymorphism in Irnian individuals with extremely low high-density lipoprotein cholesterol: Tehran lipid and glucose study.
Amar et al., "Cholesteryl ester transfer protein corrects dysfunctional high density lipoproteins and reduces aortic atherosclerosis in lecithin cholesterol acyltransferase transgenic mice," The Journal of Biological Chemistry, vol.
Lecithin cholesterol acyltransferase activity is decreased in type 2 diabetes mellitus.
In the 3 patients reported here, the lipid deposits demonstrated some similarities with lecithin cholesterol acyltransferase deficiency and lipoprotein glomerulopathy.
Decreased activation of lecithin cholesterol acyltransferase by glycated apolipoprotein.
F [right arrow] Fold Each value in mean [+ or -] SD of six separate observations P < 0.001; P < 0.0 Abbreviation HFD- high fat diet; PHLA- post-heparin lipolytic activity; PL- phospholipids; TC- total cholesterol; TG- triglycerides; LCAT- lecithin cholesterol acyltransferase; LDL- lipoprotein lipase activity; ROS- reactive oxygen spices.
Epidemiological correlates of high density lipoprotein subfractions, apolipoproteins A-I, A-II, and D, and lecithin cholesterol acyltransferase. Effects of smoking, alcohol, and adiposity.
Activity of plasma lipoprotein lipase (LPL), HMG-CoA reductase and lecithin cholesterol acyltransferase (LCAT) were assayed by the method of Korn 1955, Philipp and Shapiro (1970) and Hitz et al.
The principle of this test is measurement of the rate of cholesterol esterification ([FER.sub.HDL]) by lecithin cholesterol acyltransferase (LCAT) in plasma containing only HDLs (9).