lead optimization

lead optimization

(lēd)
The synthetic refinement of a candidate drug from its crude or original state into an agent that is safer, more useful, or more marketable.
References in periodicals archive ?
Creative Biolabs offers comprehensive services ranging from target identification and validation, hit identification, hit to lead, lead optimization to the investigational new drug (IND).
XP-103 is a dual inhibitor of tropomyosin receptor kinases and Fra-1 enzymes currently in the lead optimization stage.
Trieu will also attend the October 2019 Medicinal Chemistry Strategy Meeting US West Coast that will be held in San Francisco, California to lead an executive roundtable discussion about the integration of artificial intelligence and machine learning algorithms in new drug discovery and lead optimization, design of biomarker-driven clinical studies as well as identification of biomarker-enriched patient populations most likely to respond to new anti-cancer drug candidates, such as OT101.
The acquisition adds immediate capacity and broadens BASi's drug safety and disposition evaluations with a portfolio of tools and services including: lead optimization through candidate selection; in vivo toxicology and pharmacology; vaccine safety testing; DART; GLP in vivo services; GLP and non-GLP/ discovery bioanalysis; Histopathology including image analysis; Drug Metabolism & Pharmacokinetics; and bioequivalence testing.
Viva Biotech Group operates a leading structure-based, integrated drug discovery platform in terms of revenue in 2018 and beam time for synchrotron radiation in 2018, and provides structure-based drug discovery services to biotechnology and pharmaceutical customers worldwide for their pre-clinical stage innovative drug development, covering the full spectrum of customers' needs for early stage drug discovery, including target protein expression and structure research, hit screening, lead optimization and the drug candidate determination.
Launching three platforms, Standigm BEST[R], Standigm Insight[R], and Standigm Expander[R], Standigm has provided lead optimization, novel target analysis, and new indication prediction services to pharmaceutical companies including four global leading pharmaceutical companies.
MAP has generated a pipeline of five programs, including three that have progressed compounds through lead optimization or into IND-enabling studies.
Its customers are life scientists in pharmaceutical companies and academia doing research for drug target and validation, drug screening and lead optimization, drug development, clinical trials, and drug manufacturing.
The process of drug discovery outsourcing involves target identification, target validation, high-speed screening, and lead optimization. The final stage of drug discovery outsourcing involves obtaining a patent and running clinical trials.
Therapeutic-area-agnostic PK services support drug discovery efforts from the initial PK screening of compounds and lead optimization to late-stage candidate nomination and Investigational New Drug-enabling studies.
Under the terms of the supply and license agreement, Roche will have exclusive access to specific iCell products to be employed in High Throughput Screening (HTS) and lead optimization for drug discovery.
Utilising a proprietary technology platform, Datamyx's marketing analytics solution helps grow customer's revenue through strategic targeting, lead optimization, retention and cross-selling services.