lead compound

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lead compound

A peptide, small molecule, or other agent with pharmacological or biochemical properties which suggest that it may have therapeutic potential and value as a starting point for drug development.
References in periodicals archive ?
(Alliance News) - OKYO Pharma Ltd on Monday said it has signed a collaboration agreement with ophthalmology scientist Pedram Hamrah to evaluate proprietary lead compounds, targeting G-protein coupled receptors, as non-opioid analgesics.
"This is excellent news and I am delighted that the patent portfolio for our lead compounds continues to strengthen, add value and receive further endorsement," said chief executive Satu Vainikka.
Under the agreement, NIAID-funded contractors will evaluate Spring Bank's lead compounds in the HBV transgenic mouse model, a well-established preclinical model to assess compound efficacy.
- Canada-based biotechnology company Cyclica and Professor Igor Stagljar from the Donnelly Centre for Cellular and Biomolecular Research, Department of Biochemistry and Department of Molecular Genetics at the University of Toronto, have forged a collaboration to optimise lead compounds and de novo design of novel compounds in an effort to advance precision medicine with the next-generation EGFR-inhibitors in non-small cell lung cancer (NSCLC), the principals said.
Under the agreement, twoXAR will use its AI technology to identify a set of lead compounds which demonstrate a novel mechanism of action and will be further optimized by Ono for potential drug candidates.
According to the contract, twoXAR will use its proprietary artificial intelligence technology to identify a set of lead compounds that showcase a novel mechanism of action and will be further optimised by Ono for potential drug candidates.
To mainstream the use of certified lead safe paints by the LGUs, the group requested Ano to consider issuing a directive complementing DENR Administrative Order (A.O.) 2013-24, or the Chemical Control Order for Lead and Lead Compounds, similar to the policy issuances made by the Department of Education (DepEd) and the Department of Social Work and Development in 2017.
As per Department of Environment and Natural Resources Administrative Order 2013-24, or the Chemical Control Order for Lead and Lead Compounds, the use of lead in the manufacturing of toys, among other items, is prohibited.
Johns Hopkins University is working on a mouse model to study the neuroprotective effects of the compounds identified from the screen and studying the mechanism of action of the lead compounds. Florida State University is testing the efficacy of these compounds in a Zika virus mouse model and is also studying the mechanism of action of the lead compounds.
Danbury Pharmacal, Inc., provided a lead compound analysis for obviousness which consisted of two steps: first, determining whether a chemist of ordinary skill in the art would select the prior art compounds as lead compounds for modification and next, determining whether the prior art would provide some motivation or reason to a chemist to modify these lead compounds to make the claimed compound.
A number of lead compounds and drugs have been developed based on the concept of classical bioisosterism (Fig.
The Department of Environment and Natural Resources (DENR) will strengthen its control on the use of lead and its compounds in the local production of consumer products, as well as its importation, sale, distribution and disposal with the issuance of a chemical control order (CCO) for lead and lead compounds.