Lauric acid has a highly hydrophilic nature and therefore attracts more surface water vapor than both linoleic and oleic acids.
[14] PubChem, "'Lauric Acid,' PubChem Open Chemistry Database," [Accessed: 09-Feb-2018], https://pubchem.ncbi.nlm .nih.gov/compound/lauric_acid.
Caption: Figure 7: (a) Oleic acid [12], (b) linoleic acid [13], and (c) lauric acid [14].
Caption: Figure 8: London force on lauric acid, linoleic acid, and oleic acid.
[omega]-Hydroxylation activity of decanoic and
lauric acid by microsomal preparation of tissues of various species (14) Species [omega]-hydroxylation activity (nmole/30 min per mg protein) Liver Kidney [C.sub.10] [C.sub.12] [C.sub.10] [C.sub.12] Rat 4.48 8.40 9.33 7.22 Rabbit -- 25.22 -- 13.38 Mouse 12.60 3.74 -- 6.92 Beef 3.16 4.55 -- -- Pigeon 0.25 1.46 2.04 2.93 Bullfrog -- 19.82 -- -- Carp * -- 11.90 -- -- Species Lung [C.sub.10] [C.sub.12] Rat 0.00 0.00 Rabbit -- 22.00 Mouse -- 6.06 Beef 9.52 7.04 Pigeon 0.00 0.00 Bullfrog -- -- Carp * -- -- Abbreviations: [C.sub.10], decanoic acid: [C.sub.12],
lauric acid (dodecanoic acid) * The 10,000 x g supernatant was used for assay.
Using a gas chromatography technique, we obtained the concentration of lauric acid linked to PLL (Figure 3).
As noted for other antimicrobial compounds, the MICs of lauric acid linked to PLL were 250 [micro]M for S.
The aim in this part of the work was to study the linkage specificity of lauric acid to the [epsilon]-N[H.sub.2] lysyl of the PLL.
Secondly, lauric acid linked to PLO or to PEG performed under the same conditions as the linking of lauric acid on PLL did not show any antibacterial activity against S.
For the [C.sub.6] to [C.sub.18] fatty acids grafted on PLL, we have developed in vitro tests showing that lauryl-PLL ([C.sub.12]-PLL) exerts a significant effect at quite low concentrations of covalently linked lauric acid. A change in any of these properties could cause a loss of its antimicrobial activity [45, 46].
Free saturated fatty acids at 1mg/mL exert bacteriostatic and bactericidal activity; this activity increases with the length of the chain up to 12 carbons (lauric acid).
