Controversies Regarding Histogenesis: The source of origin of lateral periodontal cysts remains controversial, with extensive debate in the literature over whether the lesion derives from the dental lamina, reduced enamel epithelium, or rests of Malassez.3 Due to the morphologic similarity between the lateral periodontal cyst's epithelial lining, reduced enamel epithelium, and the presence of focal epithelial thickenings similar to that seen in the lining of dentigerous cysts, it has been hypothesized that the source of derivation is the reduced enamel epithelium of an erupting tooth.
The resemblance between dental lamina rests and the glycogen rich epithelial islands of the lateral periodontal cyst raises the possibility of a dental lamina source.
Botryoid variations of lateral periodontal cyst would present with multilocular appearance.
Histopathology: Lateral periodontal cyst lining is characterized by a thin cuboidal to stratified squamous non-keratinizing epithelium, ranging from one to five cell layers and presence of one or more epithelial thickenings or plaques.
Controversies Regarding Botryoid Cyst & LPC: Some controversy exists about the relationship of Botryoid odontogenic cysts to lateral periodontal cysts, as some authors prefer to define a Botryoid odontogenic cyst as a "multicystic odontogenic lesion" with histological characteristics of lateral periodontal cyst," or "cystic lesion similar to lateral periodontal cyst." (24) The Botryoid odontogenic cyst (BOC) is a polycystic variant of the lateral periodontal cyst.
Present study reported that odontogenic keratocysts had female predilection and ranked third in the cystic lesions which disagree the studies done by Jamshidi et al15 and Jones et al.16 Koseoglu et al17 showed an equal gender predilection.Current study reported that lateral periodontal cysts
accounts 6% of all odontogenic cysts which is different from the study of Altini et al.24 The most dominant site involved by lateral periodontal cysts
in this study was anterior of maxilla which is not in line to the studies by Ortega et al25 and Nikitakis et al.26 Formoso Senande et al27 showed that lateral periodontal cysts
predominantly occurred in maxilla which support this study and had a male predilection which contradict current study.
Unilocular OKCs can be located periapically, simulating periapical cysts; surrounding the crown of unerupted teeth, simulating dentigerous cysts; between the roots of teeth, simulating lateral periodontal cysts
or lateral radicular cysts; or in the maxillary midline, simulating nasopalatine duct cysts.