Orexins are produced by the lateral hypothalamus
and evidences have suggested that orexins promote energy expenditure (EE) through modulation of locomotor activity and BAT thermogenesis.
27,28] These novel ligands for orphan G-protein coupled receptors (GPCRS) were secreted from cell bodies located in the lateral hypothalamus
 which is known to regulate our food intake.
Over the location in the lateral hypothalamus
, which were initially described, the orexin and its receptors have been highlighted in neuronal bodies and positive fibers present in different regions of the central nervous system (CNS) and their position is in connection with the functions performed.
Past work has linked drug addiction and other reward-seeking behaviors, such as sex and eating, to nerve cells, or neurons, that connect the lateral hypothalamus
to the ventral tegmental area in the brain.
Tye and her team suspected that a neural pathway from the lateral hypothalamus
to the ventral tegmental area might play an important role in compulsive overeating because these brain regions have been implicated in reward-related behaviors such as eating, sexual activity, and drug addiction.
2) On the other hand Anand and Brobeck in 1951 showed that destruction of lateral hypothalamus
(LH) caused hypophagia (3,4).
On the other hand, in one of his researches, Pierre Karle (5) established that "the behavioural effects of stimulations of the lateral hypothalamus
are essentially motivational, and many other researchers considered that an unspecific appetitive or adversative behaviour is activated in such cases".
Adenosine, acting at the A1 receptor, also acts on the perifornical lateral hypothalamus
and has a regulating effect on wakefulness and somnolence, thus potentially explaining the sleepiness some patients experience after MTX dosing.
5 ml/kg, intraperitoneal) and stereotaxically implanted with a guide cannula for dialysis probe (CMA 12, Carnegie Medicine, Stockholm, Sweden) in the lateral hypothalamus
(A = -1.
The MFB originates in the reticular formation (a network of nerve fibers and cells in the brainstem), extends through the VTA and through the lateral hypothalamus
, and finally projects into the nucleus accumbens, the amygdala and the prefrontal cortex.
6) The posterior lateral hypothalamus
contains orexin neurons that are crucial for maintaining normal wakefulness.
Alternatively, neurons of the olfactory tract extend to the amygdala, which sends fibers to the lateral hypothalamus
and the NTS besides other areas (Price 2003).