Past work has linked drug addiction and other reward-seeking behaviors, such as sex and eating, to nerve cells, or neurons, that connect the lateral hypothalamus
to the ventral tegmental area in the brain.
Tye and her team suspected that a neural pathway from the lateral hypothalamus
to the ventral tegmental area might play an important role in compulsive overeating because these brain regions have been implicated in reward-related behaviors such as eating, sexual activity, and drug addiction.
Adenosine, acting at the A1 receptor, also acts on the perifornical lateral hypothalamus
and has a regulating effect on wakefulness and somnolence, thus potentially explaining the sleepiness some patients experience after MTX dosing.
5 ml/kg, intraperitoneal) and stereotaxically implanted with a guide cannula for dialysis probe (CMA 12, Carnegie Medicine, Stockholm, Sweden) in the lateral hypothalamus
(A = -1.
The MFB originates in the reticular formation (a network of nerve fibers and cells in the brainstem), extends through the VTA and through the lateral hypothalamus
, and finally projects into the nucleus accumbens, the amygdala and the prefrontal cortex.
6) The posterior lateral hypothalamus
contains orexin neurons that are crucial for maintaining normal wakefulness.
Alternatively, neurons of the olfactory tract extend to the amygdala, which sends fibers to the lateral hypothalamus
and the NTS besides other areas (Price 2003).
Its exact mechanism is unknown, but it activates neurons in the tuberomammillary nucleus and lateral hypothalamus
, resulting in histamine release, thereby promoting wakefulness (Neurosci Lett, 2003;339:143-146).
Although numerous brain areas are known to regulate feeding behavior, the lateral hypothalamus
(LH) may play a key role in regulating overeating during SSS (Rolls et al, Brain Research, 1986).
NEUROLOGICAL IMPEDANCE PATTERNS: AN INVESTIGATION INTO A POSSIBLE LINK BETWEEN THE NUCLEUS ACCUMBENS AND THE LATERAL HYPOTHALAMUS
Fessel and Forsyth (1963) demonstrated that electrical stimulation of the lateral hypothalamus
in rats increased gamma globulin levels for up to 10 days following brain stimulation.
They bind to neuropeptides Orexin-A and Orexin-B that are produced by neurons in the lateral hypothalamus
and are activated by these neuropeptides.