Lassa fever


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Lassa fever

 [las´ah]
a highly fatal acute type of hemorrhagic fever caused by a virulent arenavirus, occurring in West Africa, and characterized by progressive prostration, sore throat, ulcerations of the mouth or throat, rash, and general aches and pains, which may be followed by serous effusions, generalized hemorrhages, and fatal shock.

Las·sa fe·ver

a severe form of epidemic hemorrhagic fever, which is usually fatal. It was first recognized in Lassa (Nigeria); caused by the Lassa virus, a member of the Arenaviridae family; is characterized by high fever, sore throat, severe muscle aches, skin rash with hemorrhages, headache, abdominal pain, vomiting, and diarrhea. The multimammate rat Mastomys natalensis serves as reservoir, but person-to-person transmission is also common.

Lassa fever

(lä′sə, lăs′ə)
n.
An acute form of hemorrhagic fever endemic to West Africa that is caused by an arenavirus transmitted by a species of rat and is characterized by fever, headache, gastrointestinal symptoms, and bleeding from the gums, and can result in deafness.

Las·sa fe·ver

(lah'să fē'vĕr)
A severe form of epidemic hemorrhagic fever that is highly fatal. It was first recognized in Lassa, Nigeria; is caused by the Lassa virus, a member of the Arenaviridae family, and characterized by high fever, sore throat, severe muscle aches, rash with hemorrhages, headache, abdominal pain, vomiting, and diarrhea. The multimammate rat Mastomys natalensis serves as a reservoir, but person-to-person transmission is also common.

Lassa fever

An infectious disease caused by an arenavirus and first noted in 1969 in West Africa. The disease is maintained in the rat population and spread by rat urine. Lassa fever features a high temperature for 7 to 17 days, slow pulse, sore throat, red eyes, prostration, vomiting and pain in the chest wall and abdomen. Yellow spots and ulcers appear on the tonsils. There is a drop in the white cell count in the blood (leukopenia), internal bleeding and often liver and kidney failure. The most severely affected pass into coma and die of inadequate circulation (shock), respiratory insufficiency, or cardiac arrest. The mortality rate may be as high as 50% but many mild cases occur. Strict isolation is necessary. Treatment is with the antiviral drug RIBAVIRIN and with plasma from convalescent patients.
References in periodicals archive ?
Ten patients were medically evacuated, 6 of whom had a known or suspected exposure to Lassa fever at the time of evacuation.
While the cases are occurring during the Lassa fever season, WHO is alarmed at the 'speed of escalation'.
A 31-year-old woman residing in Gando, Oti district, presented with a suspicion of abortion; but after analyzing her history, the case of abortion due to Lassa fever was rejected.
* The report provides a snapshot of the global therapeutic landscape of Lassa Fever
WHO is supporting the ministries of health in these countries by providing Ribavirin antiviral drugs that cure Lassa fever and protective personal equipment to protect health care workers in the hospitals.
This report provides comprehensive information on the therapeutic development for Arenavirus Infection Lassa Fever, complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases.
The CDC and the New Jersey Department of Health have confirmed a death from Lassa fever which was diagnosed in a person returning to the United States from Liberia.
This volume collects 28 cases of emerging infectious diseases: severe fever with thrombocytopenia syndrome associated with a novel bunyavirus, Bas-Congo virus, hantavirus, Lassa fever, Alkhurma hemorrhagic fever, Rift Valley fever, Lujo virus hemorrhagic fever, Toscana virus, Ebola virus, Crimean-Congo hemorrhagic fever, phlebotomus fever-sandfly fever, chikungunya fever, Nipah virus disease, Middle East respiratory syndrome-coronavirus infection, human bocavirus, norovirus gastroenteritis, enterohemorrhagic E.
Vaccines for Ebola, Lassa fever and other viral haemorrhagic fevers should and could have been developed many years ago.
Another time a patient was rushed here after being diagnosed with Lassa fever following a trip to Nigeria.
Home to around 300 million people, the West African region in recent years has experienced frequent outbreak of epidemic prone diseases such as meningococcal meningitis, yellow fever, Lassa fever, cholera, polio, measles, and dengue fever.