Humans with Laron Syndrome
have dwarfism due to an inability to respond to growth hormone, which renders them cancer-free.
Untreated patients with Laron syndrome having congenital systemic IGF-I deficiency due to a GH-receptor defect never develop acne , unless substituted with high doses of recombinant IGF-I .
Laron, "Development of hyperandrogenism during treatment with insulin-like growth factor-I (IGF-I) in female patients with Laron syndrome," Clinical Endocrinology, vol.
DISCUSSION: Children with Laron syndrome clinically resemble isolated growth hormone deficiency Type 1A.
CONCLUSION: Primary GH resistance or GHIS, also known as Laron syndrome, is a hereditary disease caused by deletions or mutations in the GHR gene or the post-receptor mechanisms.
Proposed possible explanations include microcephaly, Laron Syndrome
or endemic hypothyroidism ("cretinism").
Jaime Guevara-Aguirre, an Ecuadorean physician, discovered the people--who have Laron syndrome
and are generally less than three-and-a-half feet tall--in remote villages.
floresiensis fossils exhibit 33 skeletal symptoms of Laron syndrome
, a type of insensitivity to growth hormones.
reported Tercica's phase III clinical trial data of recombinant human IGF-1 (rhIGF-1) in 65 children with severe short stature and IGF-1 deficiency caused by GH insensitivity, of whom 54 were treated for at least 1 year (45 had Laron syndrome
, 7 had GH antibodies, and 2 had unspecified defects).
The community includes many members with Laron syndrome
, a deficiency in a gene that prevents the body from using growth hormone.
Miniature humans whose prehistoric remains were recently unearthed on an Indonesian island may have had a genetic disease known as Laron syndrome
There is currently no approved treatment available for growth deficiency due to Laron syndrome