Individuals congenitally deficient in IGF-1 due to Laron syndrome
do not develop acne, for example.
Clinical reports about Laron syndrome
, primary GH insensitivity involving a molecular defect in human GHR, have also documented the development of FL, IR, and T2DM .
Another condition with serum low IGF-I levels is Laron syndrome
, the most common type of GH resistance.
Humans with Laron Syndrome
have dwarfism due to an inability to respond to growth hormone, which renders them cancer-free.
Untreated patients with Laron syndrome
having congenital systemic IGF-I deficiency due to a GH-receptor defect never develop acne , unless substituted with high doses of recombinant IGF-I .
Researchers have now tracked the health of 100 of these Ecuadorian Laron syndrome
patients for over 2 decades.
DISCUSSION: Children with Laron syndrome
clinically resemble isolated growth hormone deficiency Type 1A.
Proposed possible explanations include microcephaly, Laron Syndrome
or endemic hypothyroidism ("cretinism").
Jaime Guevara-Aguirre, an Ecuadorean physician, discovered the people--who have Laron syndrome
and are generally less than three-and-a-half feet tall--in remote villages.
floresiensis fossils exhibit 33 skeletal symptoms of Laron syndrome
, a type of insensitivity to growth hormones.
Earlier this year at the Endocrine Society meeting, Steven Chernausek, M.D., reported Tercica's phase III clinical trial data of recombinant human IGF-1 (rhIGF-1) in 65 children with severe short stature and IGF-1 deficiency caused by GH insensitivity, of whom 54 were treated for at least 1 year (45 had Laron syndrome
, 7 had GH antibodies, and 2 had unspecified defects).
The community includes many members with Laron syndrome
, a deficiency in a gene that prevents the body from using growth hormone.