Laron syndrome


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Laron syndrome

[Z. Laron, contemporary Israeli physician]
Primary insensitivity or resistance to the effects of growth hormone. It is a common cause of dwarfism. Affected individuals have high levels of circulating growth hormone, but do not make insulin-like growth factor-1 (IGF-1). They can be treated with IGF-1.
Synonym: growth hormone insensitivity syndrome
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Individuals congenitally deficient in IGF-1 due to Laron syndrome do not develop acne, for example.
Clinical reports about Laron syndrome, primary GH insensitivity involving a molecular defect in human GHR, have also documented the development of FL, IR, and T2DM [10].
Another condition with serum low IGF-I levels is Laron syndrome, the most common type of GH resistance.
Humans with Laron Syndrome have dwarfism due to an inability to respond to growth hormone, which renders them cancer-free.
Untreated patients with Laron syndrome having congenital systemic IGF-I deficiency due to a GH-receptor defect never develop acne [33], unless substituted with high doses of recombinant IGF-I [34].
Researchers have now tracked the health of 100 of these Ecuadorian Laron syndrome patients for over 2 decades.
DISCUSSION: Children with Laron syndrome clinically resemble isolated growth hormone deficiency Type 1A.
Proposed possible explanations include microcephaly, Laron Syndrome or endemic hypothyroidism ("cretinism").
Jaime Guevara-Aguirre, an Ecuadorean physician, discovered the people--who have Laron syndrome and are generally less than three-and-a-half feet tall--in remote villages.
floresiensis fossils exhibit 33 skeletal symptoms of Laron syndrome, a type of insensitivity to growth hormones.
Earlier this year at the Endocrine Society meeting, Steven Chernausek, M.D., reported Tercica's phase III clinical trial data of recombinant human IGF-1 (rhIGF-1) in 65 children with severe short stature and IGF-1 deficiency caused by GH insensitivity, of whom 54 were treated for at least 1 year (45 had Laron syndrome, 7 had GH antibodies, and 2 had unspecified defects).
The community includes many members with Laron syndrome, a deficiency in a gene that prevents the body from using growth hormone.