giant cell

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gi·ant cell

a cell of large size, often with many nuclei.
Farlex Partner Medical Dictionary © Farlex 2012
Any markedly enlarged cell seen in benign or malignant lesions; while giant cells are highly nonspecific, their presence in the proper setting supports the diagnosis of certain diseases; the epithelioid giant cells of Langhans and Touton are associated with infections and other ‘benign’ processes—e.g., sarcoidosis—have abundant cytoplasm and a rim or clutch of enlarged histiocyte-like nuclei; giant cells in tumours are less inhibited by rules of cytologic etiquette and are anointed with adjectival modifiers—e.g., bizarre, monster, osteoclastoma-like, Reed-Sternberg; the cell may be markedly enlarged and mitotically active
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

giant cell

Any markedly enlarged cell seen in benign or malignant lesions; although GCs are highly nonspecific, their presence in the proper setting supports the diagnosis of certain diseases; the epithelioid GCs of Langerhans and Touton are associated with infections and other 'benign' processes–eg, sarcoidosis, have abundant cytoplasm and a rim or clutch of enlarged histiocyte-like nuclei; GCs in tumors are less inhibited by rules of cytologic etiquette and are anointed with adjectival modifiers–eg, bizarre, monster, osteoclastoma-like, Reed-Sternberg; the cell may be markedly enlarged and mitotically active.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

gi·ant cell

(jī'ănt sel)
A cell of large size, often with many nuclei.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

giant cell

A large multinucleate cell formed from the fusion of many MACROPHAGES. Giant cells are often a feature of granulomas.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

gi·ant cell

(jī'ănt sel)
A cell of large size, often with many nuclei.
Medical Dictionary for the Dental Professions © Farlex 2012
References in periodicals archive ?
Isolated cutaneous involvement in a child with nodal anaplastic large cell lymphoma.
Goldstraw, "Large cell neuroendocrine carcinoma and large cell carcinomas with neuroendocrine morphology of the lung: Prognosis after complete resection and systematic nodal dissection," The Annals of Thoracic Surgery, vol.
Eventually the patient underwent left pneumonectomy with final histology including immunohistochemistry demonstrating anaplastic large cell lymphoma positive for CD30, Ki-67, CD45, and ALK-1 (Figure 4).
This carcinoma was histologically distinct from the previous prostate adenocarcinoma and consistent with large cell neuroendocrine carcinoma (LCNEC).
Dojcinov, "Small cell variant of anaplastic large cell lymphoma: A 10-year review of the All Wales Lymphoma Panel database: Correspondence," Histopathology, vol.
Mutation profiles of immunomarker-grouped pulmonary large cell carcinomas have been determined in prior studies with a Sequenom MassARRAY (Sequenom, San Diego, California) that targets hotspots in 8 genes, a variety of sequencing methods targeting 28 genes, and next-generation sequencing (NGS) of whole exomes in 26 genes.
Systemic ALCL which can affect all organs in the body is aggressive; and primary cutaneous ALCL which is confined to the skin is slow-growing.5 There are two subtypes: ALK-negative and ALK-positive, depending on whether the lymphoma cells produce a protein called 'anaplastic large cell kinase' (ALK).
[USPRwire, Wed Oct 07 2015] Global Markets Direct's, 'Anaplastic Large Cell Lymphoma (ALCL) - Pipeline Review, H2 2015', provides an overview of the Anaplastic Large Cell Lymphoma (ALCL)'s therapeutic pipeline.
Objective: To study the clinicopathological and immunohistochemical features of Anaplastic Large Cell Lymphoma (ALCL).
[ClickPress, Tue Mar 24 2015] Global Markets Direct's, 'Anaplastic Large Cell Lymphoma (ALCL) - Pipeline Review, H1 2015', provides an overview of the Anaplastic Large Cell Lymphoma (ALCL)'s therapeutic pipeline.
By contrast, the diagnostic accuracy in large cell carcinoma and in adenocarcinoma was 20% and 50% respectively.

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