LEP

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LEP

A gene on chromosome 7q31.3 that encodes leptin, a protein secreted by white adipocytes, which plays a key role in regulating body weight. By binding to its cognate receptor, leptin is part of a signalling pathway which inhibits food intake and regulates energy expenditure to maintain fat homeostasis. Leptin plays a role in the endocrine system, and is involved in regulating immune and inflammatory responses, haematopoiesis, angiogenesis, reproduction, glucose homeostasis, bone formation, and wound healing.

Molecular pathology
Mutations of LEP and/or its regulatory regions are linked to obesity, morbid obesity with hypogonadism, and type-2 diabetes.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
By observing the numerous ways in which a particle known as the Z [degree] can decay into other particles, another huge group of researchers working at the Large Electron-Positron collider at the European Center for Particle Physics in Geneva, Switzerland, has tentatively set an upper limit of roughly 190 GeV on the top quark's mass.
By observing the many ways in which a particle known as the Z[degree] can decay into other particles, researchers working with the ALEPH detector at the Large Electron-Positron collider in Geneva, Switzerland, have now obtained the msot stringent limit yet excluding the existence of a fourth generation of elementary particles.
* Z[degree] particles were produced, first at the Stanford Linear Collider, then at the Large Electron-Positron collider at CERN (135: 245; 136: 159).

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