M2 PHARMA-March 29, 2019-Oragenics Enters into Collaboration with Florida International University to Expand Its Pipeline of Lantibiotics
Net proceeds may be used by the company to fund its AG013 research, clinical trials, pre-clinical development of the lantibiotics
programme, working capital as well as general corporate purposes.
Liquid chromatography mass spectrometry detected the presence of lantibiotics
A, D, M, I and T, confirming all genes were expressed.
* Willey JM, Van der Donk WA (2007) Lantibiotics
: peptides of diverse structure and function, Annu.
(2015) reported that the production of class I lantibiotics
) by B.
salivarius M18 produces are in a class called lantibiotics
that use a mode of action that literally creates a hole, or pore, in the target organism's cell membrane leading to its destruction.
Automobiles, telephones, lantibiotics
, and personal computers are just a few 20th century examples.
Evaluating the feasibility of lantibiotics
as an alternative therapy against bacterial infections in humans.
Based on their molecular structure, bacteriocins can be divided into four groups: class I bacteriocins contain posttranslational modifications (lantibiotics
and molecular weight [less than or equal to] 5kDa); class II bacteriocins are unmodified and include small, heat-stable nonlanthionine-containing peptides .
Several experimental studies have been done on the posttranslationally modified antimicrobial peptides known as lantibiotics
More specifically, lantibiotics
are an important family of heat stable low molecular weight bacteriocins that possess unusual posttranslationally modified amino acids, such as lanthionine, methyllanthionine, dehydroalanine, and dehydrobutyrine with thioether linkages .
The bacteriocin that belongs to the group of lantibiotics
, in several variants differing in amino acid sequence in their structures, is produced by bacterial strains possessing specific genome.