(NYSE American: OGEN) has initiated a collaboration with Florida International University to create computational models of the company's lantibiotic
compounds interacting with bacterial membranes and Lipid II, the target of Oragenics' compounds with the ultimate goal of expanding the lantibiotic
pipeline, the company said.
Formicin-a novel broad-spectrum two-component lantibiotic
produced by Bacillus paralicheniformis APC 1576.
Oragenics announced the publication of a research paper entitled "OG716: designing a fit-for-purpose lantibiotic
for the treatment of Clostridium difficile infections" in PLOS ONE, a peer-reviewed open access scientific journal published by the Public Library of Science.
Bisin is a broad spectrum lantibiotic
produced by Bifidobacterium longum DJO10A.
Hansen, "Identification and characterization of the structural and transporter genes for, and the chemical and biological properties of, sublancin 168, a novel lantibiotic
produced by Bacillus subtilis 168," Journal of Biological Chemistry, vol.
Nisin is an important bacteriocin AMP and one of the most studied lantibiotic
which has a 34 amino acid including lanthionine and methyl-lanthionine.
They reported the antimicrobial activity of Nisin (an antimicrobial peptide belonging to the family of the lantibiotic
) against Gram-positive bacteria.
Salivaricin 9, a new lantibiotic
produced by Streptococcus salivarius.
(2011) Sublancin is not a lantibiotic
but an S-linked glycopeptide.
Nisin, a lantibiotic
produced by Lactococcus lactis subsp.
Grenier, "Suicin 90-1330 from a non-virulent strain of Streptococcus suis: a nisin-related lantibiotic
active on gram-positive swine pathogens," Applied and Environmental Microbiology, vol.
Sonomoto, "Identification of the lantibiotic
nisin q, a new natural nisin variant produced by lactococcus lactis 61-14 isolated from a river in japan," Bioscience, Biotechnology, and Biochemistry, vol.