Langhans cells

Lang·hans cells

(lahng'hahnz),
1. multinucleated giant cells seen in tuberculosis and other granulomatous diseases; the nuclei are arranged in an arciform manner at the periphery of the cells; Synonym(s): Langhans-type giant cells

Lang·hans cells

(lahng'hahnz selz)
1. Multinucleated giant cells seen in tuberculosis and other granulomatous diseases; the nuclei are arranged in an arciform manner at the periphery of the cells.
Synonym(s): Langhans-type giant cells.
2. Synonym(s): cytotrophoblastic cells.

Langhans,

Theodor, German pathologist, 1839-1915.
Langhans cells - multinucleated giant cells seen in tuberculosis and other granulomas. Synonym(s): cytotrophoblastic cells; Langhans-type giant cells
Langhans layer - the inner layer of the trophoblast. Synonym(s): cytotrophoblast
Langhans stria - fibrinoid that accumulates on the chorionic plate between the bases of placental villi during the first half of pregnancy.
Langhans-type giant cells - Synonym(s): Langhans cells
References in periodicals archive ?
Lord, "Langhans cells of human arterial intima: Uniform by stellate appearance but different by nature," Tissue & Cell, vol.
Caption: Figure 2: Histopathological picture showing epithelioid cells, Langhans cells, and foci of caseous necrosis.
HPE showed Langhans cells and AFB staining positive for two.
HPE of the tissue showed positive for Langhans cells with AFB +ve.
In mid-borderline leprosy, grenz zone in 75%, AFB in 50% cases by ZN stain and 75% cases by modified Fite stain, macrophage predominance of infiltrate in 75% cases, perivascular and periappendiceal infiltrate in 50%, immature epithelioid granuloma and obliteration of nerve by granuloma in 33.33% of cases, and lymphocyte predominance of infiltrate, macrophage granuloma, and presence of Langhans cells each in 25% of cases were seen.
Macrophages in granulomas may fuse to form multinucleated giant cells, Langhans cells. Local secretion of the cytokine TNF is required for optimal granuloma structure.
We also found an attributable risk of 52,3% for the development of caseum necrosis and presence of Langhans cells. Conclusions: We found higher presence of mycobacterium in HIV positive patients and higher presence of caseum necrosis in HIV negative patients.
The numerous epithelioid granulomas contained Langhans cells and foreign body giant cells, while the necrotizing lesions contained neutrophilic and eosinophilic infiltrates.