Langerhans cells


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Lan·ger·hans cells

(lahng'ĕr-hahnz),
1. dendritic clear cells in the epidermis, containing distinctive granules that appear rod- or racket-shaped in section, but lacking tonofilaments, melanosomes, and desmosomes; they carry surface receptors for immunoglobulin (Fc) and complement (C3), and are believed to be antigen fixing and processing cells of monocytic origin; active participants in cutaneous delayed hypersensitivity. Synonym(s): interdigitating dendritic cells
2. cells seen in eosinophilic granuloma and lymphoma of the lungs.
Synonym(s): dendritic cell

Lan·ger·hans cells

(lahng'er-hahnz selz)
1. Dendritic clear cells in the epidermis containing distinctive granules but lacking tonofilaments, melanosomes, and desmosomes; they carry surface receptors for immunoglobulin (Fc) and complement (C3), and are believed to be antigen-fixing and processing cells of monocytic origin; active participants in cutaneous delayed hypersensitivity.
2. Cells seen in eosinophilic granuloma and lymphoma of the lungs.

Langerhans cells

cells involved in the presentation of antigens to bring about an immune response; such cells are found in the skin and the gastrointestinal tract.

Langerhans,

Paul, German anatomist, 1847-1888.
islets of Langerhans - cellular masses composed of different cell types that comprise the endocrine portion of the pancreas and are the source of insulin and glucagon. Synonym(s): islet tissue; Langerhans islands; pancreatic islands; pancreatic islets
Langerhans cell granulomatosis
Langerhans cells - dendritic clear cells in the epidermis that are active participants in cutaneous delayed hypersensitivity.
Langerhans granule - a small membrane-bound granule first reported in Langerhans cells of the epidermis. Synonym(s): Birbeck granule
Langerhans islands - Synonym(s): islets of Langerhans

Lan·ger·hans cells

(lahng'er-hahnz selz)
Dendritic clear cells in epidermis, containing distinctive granules that appear rod- or racket-shaped in section, but lacking tonofilaments, melanosomes, and desmosomes.
References in periodicals archive ?
Langerhans cell histiocytosis: Histiocyte society evaluation and treatment guidelines.
Histiocytic sarcoma (G), like Langerhans cell sarcoma (H), demonstrates large pleomorphic atypical cells; however, the cells of histiocytic sarcoma are generally larger than those of Langerhans cell sarcoma and show less nuclear complexity (hematoxylin-eosin, original magnification X400).
Langerhans cell histiocytosis and choledocholithiasis: is there an association?
Daniel, "Isolated langerhans cell histiocytosis bone lesion in pediatric patients: systematic review and treatment algorithm," Otolaryngology --Head and Neck Surgery, vol.
Nakamura et al., "Severe dermatitis with loss of epidermal Langerhans cells in human and mouse zinc deficiency," The Journal of Clinical Investigation, vol.
Moreover, we [37] and others have tracked bone marrow-derived dendritic cells, that present dendritic cell phenotype and functions; however it is not expected that these cells behave as Langerhans cells even if they are injected into the skin.
Cochran, "Quantitative alterations in cutaneous langerhans cells during the evolution of malignant melanoma of the skin," Journal of Investigative Dermatology, vol.
Brown, "Langerhans cell histiocytosis a clinicopathologic review and molecular pathogenetic update," Archives of Pathology & Laboratory Medicine, vol.
MUTZ-3 derived Langerhans cells in human skin equivalents show differential migration and phenotypic plasticity after allergen or irritant exposure.
The histiocytes showed nuclear groove and kidney bean-shaped nuclei typical of Langerhans cells [Figure 3]a and clusters of foamy histiocytes [Figure 3]b were seen in BAL cytology.
(22) A star-shaped immune cell in the skin called the Langerhans cell has long cellular extensions, or "arms" called dendrites, stretching to the surface of skin.
While ECD and RDD could be differentiated pathologically (lack of emperipolesis) or clinically (no massive lymphadenopathy) [14], immunohistochemistry performed on bone marrow (or soft) tissue is essential in distinguishing Langerhans cells from non-Langerhans histiocytes.

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