Langerhans cell


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Langerhans cell

(läng′ər-häns′)
n.
An antigen-presenting dendritic cell of the epidermis, containing characteristic rod-shaped granules (Birbeck granules). Langerhans cells are thought to stimulate T cells in lymph nodes to which they migrate and also T cells in the skin.

Langerhans cell

An antigen-presenting dendritic cell found in the skin. These cells pick up and process antigen in the skin and then move to the nearest lymph node where the antigen is presented to T cells. In this way the immune system may become sensitized to a contact allergen. (Paul Wilhelm Langerhans 1847–88, German physician, who described these cells when he was a medical student.)
References in periodicals archive ?
Diagnosis of central diabetes insipidus in children is straightforward when central diabetes insipidus follows a recent history of meningitis, neurosurgery, trauma, or known disease like Langerhans cell histiocytosis (3,6).
Dramatic efficacy of vemurafenib in both multisystemic and refractory Erdheim-Chester disease and Langerhans cell histiocytosis harboring the BRAF V600E mutation.
Incidence and survival of childhood Langerhans cell histiocytosis in Northwest England from 1954 to 1998.
Langerhans cell sarcoma arising from chronic lymphocytic lymphoma/small lymphocytic leukemia: lineage analysis and BRAF V600E mutation study.
Elevated serum levels of the decoy receptor osteprotegerin in children with Langerhans cell histiocytosis.
Langerhans cell histiocytosis comprise 7%-10.8% of scalp masses in children (13).
Skeletal involvement in Langerhans cell histiocytosis.
Bone marrow findings at diagnosis in patients with multisystem langerhans cell histiocytosis.
Allen, "Progress in understanding the pathogenesis of Langerhans cell histiocytosis: back to Histiocytosis X?" British Journal of Haematology, vol.
The overall incidence of orbital Langerhans Cell Histiocytosis is estimated to be 20%, most commonly as eosinophilic granuloma.
We report a case of RDD with multiple skin lesions and pulmonary CT manifestations mimicking Langerhans cell histiocytosis, which improved after initiation of corticosteroid treatment.
This classification was constructed as follows: Langerhans cell histiocytosis (LCH), Langerhans cell sarcoma, interdigitating dendritic cell sarcoma, follicular dendritic cell sarcoma/tumor, and other rare dendritic cell tumors (i.e., fibroblastic reticular cell tumor and indeterminate dendritic cell tumor).

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