In vitro reconstructed mucosa-integrating Langerhans' cells
histiocytosis (LCH) is a rare clonal disorder of proliferating histiocytic cells expressing phenotypic markers of the epidermal Langerhans' cells
The stellate shape of PLCH lesions (f) may be obscured by surrounding fibrosis; however, (g) even in the absence of obvious Langerhans' cells
, the typical polymorphous mixture of lymphocytes, plasma cells, and eosinophils (arrowheads) is diagnostic (hematoxylin-eosin, original magnifications X12.
22) Ultraviolet light destroys specialized immune cells called Langerhans' cells
that are abundantly found in the skin (22) and are responsible for destroying harmful substances such as germs, toxins, tumors, or other invaders before they can hurt the skin or penetrate further into the body.
Pulmonary Langerhans'-cell histiocytosis LCH) forms part of a spectrum of diseases characterized by monoclonal proliferation and infiltration of organs by Langerhans' cells
The first study, conducted by Australian researchers, has shown that the inner foreskin has the largest concentration of Langerhans' cells
, which are the initial cellular targets in the sexual transmission of HIV.
The Histiocytes International Society classifies the histiocytosis in three large groups: Langerhans' cells
histiocytosis, monocytes/macrophages cells histiocytosis different from Langerhans' cells
(among them the RDD and JXG) and the harmful histiocytic disorders.
These cells, called Langerhans' cells
, "tend to be close to the surface," he says.
7) Because Langerhans' cells
are the only monoclonal cells in LCH, Egeler et al speculated that LCH is a type of neoplastic phenomenon.
To extend this observation, epidermal Langerhans' cells
(LC) were treated with concentrations of BE from 10 4 to 10-12 in vitro followed by determination of major histocompatability complex class II expression and protein synthesis.
Ultraviolet radiation has an extremely adverse effect on the immune system by suppressing the function of specialized cells, called Langerhans' cells
, which activate the system," she says.