an obsolete, nonspecific test for altered proteins in spinal fluid. As originally used by Lange in 1912, the test was thought to be specific for neurosyphilis; however, this proved to be incorrect. Dilutions of spinal fluid are made in saline and to these a colloidal gold solution is added; if altered proteins are present, there is a color change or precipitate formed.
[Carl Lange, Ger. physician, 1883–1953]
An obsolete test for diagnosis of cerebrospinal syphilis by the degree of gold precipitation in varying concentrations of colloidal gold solution and spinal fluid.
Lange,Carl F.A., German biochemist, 1883-1953.
Lange solution - a colloidal gold solution used to demonstrate protein abnormalities in spinal fluid.
Lange test - an obsolete, nonspecific test for altered proteins in spinal fluid. Synonym(s): gold sol test; Zsigmondy test