LGALS3

(redirected from Laminin-binding protein)

LGALS3

A gene on chromosome 14q22.3 that encodes a galectin family-type carbohydrate-binding protein, which can self-associate through the N-terminal domain, bind to multivalent saccharide ligands and localise to the extracellular matrix, cytoplasm and nucleus. The LGALS3 protein product plays a role in various cell functions including apoptosis, innate
immunity, cell adhesion and T-cell regulation.
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In addition to various FBPs, we previously characterized a 34-kDa laminin-binding protein (Lbp) in an M12 strain.
2002) Novel laminin-binding protein of Streptococcus pyogenes, Lbp, is involved in adhesion to epithelial cells.
2005) Immune response to a laminin-binding protein (Lmb) in group A streptococcal infection.
Notably, two of the downregulated proteins, protein S100-A4 (S100A4) and laminin-binding protein (RPSA) are known to play key roles in driving metastasis and were verified using Western blotting.
Rabbit monoclonal antibodies against protein S100-A4 (S100A4) (ab124805) and laminin-binding protein (RPSA) (ab133645) were purchased from Abeam (Cambridge, UK).
Equivalent amounts of protein samples (20 [micro]g/lane) were resolved using 10% or 12% SDS-PAGE to visualise laminin-binding protein (RPSA), E-cadherin, total and phospho-ERK1/2 (p-ERK1/2), as well as total and phospho-NF-[kappa]B p65 (p-NF-[kappa]B p65).
leprae, (22) and a histone-like, laminin-binding protein (Hlp/LBP) expressed by M.