laminin 5


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Related to laminin 5: LAMA5

laminin 5

A complex glycoprotein composed of three subunits (alpha, beta and gamma), which is involved in:
• Cell adhesion via integrin alpha-3/beta-1 in focal adhesion and integrin alpha-6/beta-4 in hemidesmosomes;
• Signal transduction via tyrosine phosphorylation of pp125-FAK and p80; and
• Keratinocytes differentiation.
References in periodicals archive ?
Now the nosological status of Shabbir's syndrome has been finally established as a subtype of junctional epidermolysis bullosa (JEB),7,8 since it is associated with mechanical fragility of the skin, ultrastructural features of the hemidesmosomes consistent with junctional EB, and mutations in the laminin 5 gene; however, it has distinct clinicopathological features and molecular findings which differentiate it from other variants of JEB.
Deposition of laminin 5 in epidermal wounds regulates integrin signaling and adhesion.
Anti-basement membrane autoantibodies in patients with anti-epiligrin cicatricial pemphigoid bind the alpha subunit of laminin 5. J Invest Dermatol 1995;105:543-8.