light chain

(redirected from Lambda light chain)
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chain

 [chān]
a collection of objects linked together in linear fashion, or end to end, as the assemblage of atoms or radicals in a chemical compound, or an assemblage of individual bacterial cells.
branched chain an open chain of atoms, usually carbon, with one or more side chains attached to it.
closed chain several atoms linked together so as to form a ring, which may be saturated, as in cyclopentane, or aromatic, as in benzene.
H chain (heavy chain) any of the large polypeptide chains of five classes that, paired with the L or light chains, make up the antibody molecule of an immunoglobulin; heavy chains bear the antigenic determinants that differentiate the classes of immunoglobulins. See also heavy chain disease.
J chain a polypeptide occurring in polymeric IgM and IgA molecules.
L chain (light chain) either of the two small polypeptide chains (molecular weight 22,000) that, when linked to H or heavy chains by disulfide bonds, make up the antibody molecule of an immunoglobulin monomer; they are of two types, kappa and lambda, which are unrelated to immunoglobulin class differences.
open chain a series of atoms united in a straight line; components of this series are related to methane.
chain reaction a chemical reaction that is self-propagating; each time a free radical is destroyed a new one is formed.
side chain a group of atoms attached to a larger chain or to a ring.

light chain

a polypeptide chain of low molecular weight, such as the κ or λ chains in immunoglobulin. There are two identical κ- or λ-light chains in each immunoglobulin monomer.
Synonym(s): L chain

light chain

n.
The smaller of the two types of polypeptide chains in immunoglobulins, consisting of an antigen-binding portion with a variable amino acid sequence, and a constant region with an amino acid sequence that is relatively unchanging.

light chain

(līt chān)
A polypeptide chain with low molecular weight, as the κ or λ chains in immunoglobulin.

light chain

see IMMUNOGLOBULIN.
References in periodicals archive ?
Although our patient did not have a demonstrable paraprotein, he had a proven plasmacytoma with lambda light chain clonality, which has been reported in previous literature regarding POEMS [10,11].
Based on the findings presented in this report, we hypothesize that the ferret Ig[lambda] locus more closely resembles the human Ig[lambda] locus than the mouse Ig[lambda] loci due to the increase proportion of B cells that express a lambda light chain (Figure 8(c)).
[6] Bcl2, BOB1, OCT2, HHV8 CD38 (focal) Lambda light chains Negative IS: CD20, CD79a, CD3, PAX5, CD30, CD15,CD138,ALK Ferry et M/61 Positive IS:HHV8, CD45, al.
He thus had evidence of solitary plasmacytoma of bone (SPB) based on the presence of a biopsy-proven solitary plasma cell neoplasm arising from the sacrum associated with systemic features not amounting to smoldering or overt multiple myeloma (monoclonal lambda light chain gammopathy with serum M band < 1g/dL, <10% bone marrow involvement with clonal plasma cells, and absence of associated end organ dysfunction) [6].
Interpretation In summary, the patient has a mild plasmacytosis on the biopsy (~5-10%) that is lambda light chain restricted.
Metachronous development of nonamyloidotic lambda light chain deposition disease and IgG heavy chain amyloidosis in the same patient.
Assessment of cerebrospinal fluid immunoglobulin patterns after isoelectric focusing: use of kappa and lambda light chain immunoperoxidase staining.
Flow cytometric analysis of kappa and lambda light chain expression in evaluation of specimens for B-cell neoplasia.
The panel of monoclonal antibodies included: CD3; CD8; CD20; CD30; CD43; CD45RB; CD45RO; CD56; CD68; CD79a; immunoglobulin kappa light chain; immunoglobulin lambda light chain; ALK-1; epithelial membrane antigen (EMA); and AE1/AE3 (Dako Corporation, Carpinteria, Calif).
Kappa and lambda light chains were expressed in the infiltrate, with no restriction and no monoclonality.
Serum free kappa and lambda light chains were mildly elevated but with a normal free kappa-lambda ratio of 1.66.
In panel B, separated immunoglobulins in the patient's serum were visualized by use of IFE with antisera against human immunoglobulins G, A, and M, and against human kappa and lambda light chains in lanes marked G, A, M, K, and L, respectively.