Rabbit hemorrhagic disease virus (RHDV) is a calicivirus in the genus Lagovirus
causing acute hepatic necrosis in European rabbits (Oryctolagus cuniculus), leading to disseminated intravascular coagulation and death in [greater than or equal to]90% of susceptible animals (1).
Family Caliviridae includes non-enveloped viruses with single-stranded positive sense RNA classified into 4 genera by the International Committee on the Taxonomy of Viruses (ICTV) in 2002: Norovirus, Sapovirus, Vesivirus and Lagovirus
The family consists of the genera Vesivirus, Lagovirus
, Norovirus, Sapovirus, and Nebovirus as well as unassigned caliciviruses (1,2).
RHD is caused by Rabbit hemorrhagic disease virus (RHDV; genus Lagovirus
, family Caliciviridae) (4), a virus with a positive-sense, single-stranded RNA genome of 7.
The family Caliciviridae consists of 5 genera, Norovirus, Sapovirus, Lagovirus
, Vesivirus, and Nebovirus, and 3 proposed genera, Recovirus, Valovirus, and chicken calicivirus (8-10).
To the Editor: Rabbit hemorrhagic disease virus (RHDV) is a calicivirus of the genus Lagovirus
that causes epidemics of an acute disease and mortality rates of 50%-90% among rabbits.
They have been classified into 5 genera (Norovirus, Sapovirus, Vesivirus, Lagovirus
, and Nebovirus) since 2009 (www.
However, they did not include the publicly available sequences of other nonpathogenic strains, such as Ashington (97% of the capsid viral protein [VP] 60) and the newly identifi ed Lagovirus
RHDV is classified as a Lagovirus
within the family Caliciviridae.
The family Caliciviridae contains 4 genera (Sapovirus, Norovirus, Lagovirus
, and Vesivirus), which include Sapporo virus, Norwalk virus, Rabbit hemorrhagic disease virus, and Feline calicivirus, respectively.
The family Caliciviridae contains 4 genera, Sapovirus, Norovirus, Lagovirus
, and Vesivirus, which include sapovirus (SaV), norovirus (NOV), rabbit hemorrhagic disease virus, and feline calicivirus strains, respectively.
The duplication of a conserved sequence at the start of ORF1 and ORF2 is characteristic of caliciviruses and is seen in all 4 genera, NoV, sapovirus, lagovirus
, and vesivirus (5,26-28).