The study authors write: "Purpose in life may affect risk for cerebral infarcts, specifically macroscopic lacunar infarcts
A computed tomography scan of his head identified several infarcts in the territories of the left middle cerebral artery, the left and right posterior cerebral artery, and lacunar infarcts
in the left basal ganglia and right thalamus.
All those events are consistent with a diagnosis of lacunar infarcts
in the deep tissues of the brain.
compared 68 ischemic stroke patients to 51 controls and found that the serum S100B levels of the patients were higher than that of the controls due to the size of infarction in TACI and lower in lacunar infarcts
Brain MRI confirmed lacunar infarcts
in the centrum semiovale bilaterally and bilateral watershed territory infarcts suggestive of a vasculopathy.
Subjects with a history of more than one stroke and subjects with lacunar infarcts
The most widely accepted classification of ischemic stroke is based on TOAST criteria which divides ischemic stroke into five categories, namely--large artery atherosclerosis, cardioembolism, small vessel occlusion (lacunar infarction), undetermined etiology and multiple possible etiologies [5,6] Another method of classification is modified Oxfordshire method, based on the anatomic distribution of infarcts-- total anterior circulation infarcts, partial anterior circulation infarcts, posterior circulation infarcts, watershed infarcts, centrum ovale infarcts and lacunar infarcts
The presence of lacunar infarcts
at baseline was associated with a fourfold higher risk for new deep or infratentorial microbleeds at follow-up than in people without infarcts.
22) The results of neuropathological examinations demonstrated that among participants who met pathological criteria for AD, those who additionally demonstrated brain infarcts had more severe dementia, that fewer pathological lesions of AD (plaques and tangles, P&T) were required to produce dementia in those with lacunar infarcts
, and those with P&T or brain infarcts alone were less likely to have clinical dementia.
Pathologically, the white matter lesions are a combination of lacunar infarcts
, demyelination, and gliosis; all are due to small vessel disease and decreased blood flow and tissue perfusion.
Well-delineated areas of abnormal signal (decreased on T1-weighted and increased on T2-weighted imaging) demonstrating lacunar infarcts
are identified in the frontal, parietal, and occipital subcortical white matter and basal ganglia.
Among the causes that might explain some organic pathologies are lacunar infarcts
, sclerosis, brain lesions, and arteriovenous malformations.