The first group, CST I, is dominated by Lactobacillus crispatus
, which according to the Dr.
This study involved 100 reproductive-aged women (18 to 40 years) with recurrent urinary tract infections (UTI) and current acute, symptomatic, uncomplicated bladder infections who were randomized to receive either Lactobacillus crispatus
of 10 billion CFUs or placebo suppositories daily for 5 days, then once weekly for 10 weeks.
a product containing Lactobacillus crispatus
, or placebo (Clin.
Evaluation of random amplified polymorphic DNA (RAPD)-PCR as a method to differentiate Lactobacillus acidophilus, Lactobacillus crispatus
, Lactobacillus amvlovorus.
These include BufferGel, ACIDFORM gel, Lactobacillus crispatus
suppository and genetically modified strains of Lactobacillus.
In the trial, treatment with CTV-05 resulted in vaginal colonization by lactobacillus crispatus
in 62% of patients at 30 days compared to 2% on placebo (p-value less than 0.
Early trials assessing the efficacy of intravaginal capsules containing the probiotic Lactobacillus crispatus
have proven "very disappointing," she said.
Early results with the Lactobacillus crispatus
CTV-05 strain have not shown a benefit, he said at the conference sponsored by the American Society for Colposcopy and Cervical Pathology.
LACTIN-V contains a natural human bacterium, Lactobacillus crispatus
, which has been carefully selected based upon detailed scientific findings that demonstrate its unique ability to colonize the vaginal mucosa and to secrete substances that inhibit the growth of microbial pathogens.
is the dominant strain of Lactobacillus in the urogenital tract.
Among other management strategies for treating recurrent BV, he listed condoms, intravaginal use of Lactobacillus crispatus
, oral or vaginal use of yogurt containing L.
Particularly significant was the fact that D2A21 was effective at concentrations that do not negatively effect Lactobacillus crispatus