Lobomycosis (lacaziosis) is a chronic subcutaneous mycosis caused by the still uncultured fungus Lacazia loboi (1).
Molecular model for studying the uncultivated fungal pathogen Lacazia loboi. J Clin Microbiol.
Lobomycosis is a subcutaneous mycosis caused by Lacazia loboi
and Rhinosporidium seeberi: a genomic perspective.
The clinical and phenotypic features of the uncultivated agent of lacaziosis/lobomycosis in dolphins suggested that this pathogen was the same organism as Lacazia loboi, which causes skin keloidal-like lesions in humans (1-6).
Her research interests include Lacazia loboi, Lagenidium spp., Pythium insidiosum, and Rhinosporidium seeberi.
It is caused by the noncultivable yeast-like organism (Lacazia loboi
) of the order Onygenales (7).
Lacazia loboi is a fungus (order Onygenales) that has not yet been cultured (1).
The taxonomic status of Lacazia loboi and Rhinosporidium seeberi has been finally resolved with the use of molecular tools.
Unfortunately, the etiologic agent of lobomycosis, Lacazia loboi
(Figure), has not been cultured in vitro (10) despite exhaustive attempts, making its isolation from probable and suspected environmental sources impossible.
The causative agent is Lacazia loboi
(2), a fungus of uncertain phylogeny, which causes an inflammatory infiltrate accompanied by the formation of a granuloma in which giant cells phagocytose a larger number of fungi (3,4).
The nomenclature of the fungus has been subject to ongoing debate, although a new genus, Lacazia, with Lacazia loboi
as the type species, was recently proposed by Toborda et al.