storage lesion

(redirected from Labile proteins)

storage lesion

Transfusion medicine The constellation of changes occurring in a unit of packed red cells during storage. See Red cell preservatives.
Storage lesions
Ammonium to 470 µmol/L–US: 800 µg/dL
Free Hb in plasma from 82 to 6580 mg/L–US: 8.2 to 658 mg/dL
K+ from 4.2 to 78.5 mmol/L–US: 4.2 to 78.5 mEq/L
ATP from 100% to 45%
2,3 DPG to < 10% of original levels–replenished within 24 hours of transfusion
Labile proteins, eg complement, fibronectin and coagulation factors ↓ to negligible
Na+ from 169 to 111 mmol/L–US: 169 to 111 mEq/L
pH from 7.6 to 6.7
Adverse physiologic effects of stored blood is negligible in the absence of a previous compromise of the Pt's–recipient's status

storage lesion

In blood banking and transfusion therapy, the biochemical and structural degradation of blood cells that occurs over time.
See also: lesion
References in periodicals archive ?
Perfusion can enable manufacture of inherently less-stable and labile proteins. Also, better-quality products can be produced by comparable batch-type manufacture with lower costs compared to batch processing.
Patients sensitized to these labile proteins are more likely to tolerate or experience only mild, local symptoms to these less stable components, whereas stable protein components are frequently associated with more severe symptoms.
The proteins of the nuclear matrix has been recognized as the most thermal labile proteins in the cell (29).