The graph shows changes of heart weight/body weight ratio (A) and indexes of cardiac function including LVSP (B), LVEDP
(C), + [LVdP/dt.sub.max] (D), and - [LVdP/dt.sub.max] (E) measured in WKY + Sed, WkY+ Exe, SHR + Sed and SHR+ Exe groups.
This conclusion is supported by the data (Table I) indicating that CUS markedly increased LVEDP
and significantly decreased LVSP and both maximum LV contractility (+dp/dt max) and maximum LV relaxation (dp/dt max), which are indications of heart failure (Danzmann et al., 2008) that were corrected by quercetin.
In this study, we show that EF, FS, and LVSP levels were significantly decreased, while LVEDP
levels were increased in I/R rats.
LVSP: left ventricular systolic pressure; LVEDP
: left ventricular end-diastolic pressure; LV [+ or -]dP/dt max: the instantaneous first derivation of left ventricle pressure.
Our experimental research showed that, compared with control and sham operation group, LVESP and LV [+ or -] dp/[dt.sub.max] decreased significantly, and LVEDP
, left ventricular weigh, and left ventricular weight index increased significantly 2 weeks after AMI in AMI group and the three drug-treated groups.
Together, they cause increase in LVEDP
and decreased cardiac function.
Any heart with a HR < 250 beats/min, CF > 18 mL/min or < 8 mL/min, or LVDP < 80 mmHg when the LVEDP
was maintained at 5-10 mmHg at the end of stabilization was excluded from the study.
In addition, the decrease in preload decreases left ventricular end-diastolic volume (LVEDV) and pressure (LVEDP
), thus promoting better coronary perfusion pressure due to a greater pressure gradient (coronary perfusion pressure = diastolic pressure--left ventricular end diastolic pressure).
LHC revealed markedly elevated left ventricular end diastolic pressure (LVEDP
The following functional parameters were measured: left ventricular systolic pressure (LVSP), left ventricular end-diastolic pressure (LVEDP
, LVDP = LVSP - LVEDP
), [+ or -]dp/[dt.sub.max] (reflecting the important indicators of left ventricular systolic function and diastolic function), and heart rate (HR) were detected uninterruptedly using 4S AD instruments biology polygraph (Power lab, Australia).
Data included an electrocardiogram (ECG), heart rate (HR, beats/min.), mean right-atrial (RAP, mm Hg) and pulmonary-artery (PAP, mm Hg) systolic (SAP), diastolic (DAP), and mean (MAP) arterial pressures (mm Hg), and left ventricular end systolic (LVESP, mm Hg) and end diastolic pressures (LVEDP
, mm Hg).
Hearts were harvested and ex vivo perfused in the Langendorff System and myocardial function was determined by measuring the left ventricular end diastolic pressure (LVEDP
) and left ventricular systolic pressure (LVSP).