LTRPC2 | definition of LTRPC2 by Medical dictionary
TRPM2 (redirected from LTRPC2)
TRPM2 A gene on chromosome 21q22.3 that encodes a nonselective, voltage-independent cation channel, which mediates sodium and calcium ion influx in response to oxidative stress. TRPM2 is activated by ADP-ribose, NAD+, reactive oxygen species and arachidonic acid; it confers susceptibility to cell death in response to oxidative stress, and is inactivated by intracellular ATP.
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References in periodicals archive
[Ca.sub.2+]-permeable channel activated by changes in redox status confers susceptibility to cell death.
Dunn et al., "ADP-ribose gating of the calcium-permeable LTRPC2
channel revealed by Nudix motif homology," Nature, vol.
Ca2+permeable channel activated by changes in redox status confers susceptibility to cell death.
The [Ca.sup.2+]-permeable TRPM2 channels, formerly known as TRPC2 and LTRPC2
, were first identified in 1998 .