TRPM2

(redirected from LTRPC2)

TRPM2

A gene on chromosome 21q22.3 that encodes a nonselective,  voltage-independent cation channel, which mediates sodium and calcium ion influx in response to oxidative stress. TRPM2 is activated by ADP-ribose, NAD+, reactive oxygen species and arachidonic acid; it confers susceptibility to cell death in response to oxidative stress, and is inactivated by intracellular ATP.
References in periodicals archive ?
(2002) LTRPC2 [Ca.sub.2+]-permeable channel activated by changes in redox status confers susceptibility to cell death.
TRP channels in oxygen physiology: distinctive functional properties and roles of TRPA1 in [O.sub.2] sensing
Dunn et al., "ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology," Nature, vol.
Markers and Biomarkers of Endothelium: When Something Is Rotten in the State
LTRPC2 Ca2+permeable channel activated by changes in redox status confers susceptibility to cell death.
Genome-wide characterization of circulating tumor cells identifies novel prognostic genomic alterations in systemic melanoma metastasis
The [Ca.sup.2+]-permeable TRPM2 channels, formerly known as TRPC2 and LTRPC2, were first identified in 1998 [4].
Targeting TRPM2 Channels Impairs Radiation-Induced Cell Cycle Arrest and Fosters Cell Death of T Cell Leukemia Cells in a Bcl-2-Dependent Manner
Medical browser ?
Full browser ?