LTBR


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LTBR

A gene on chromosome 12p13 that encodes lymphotoxin beta receptor, which belongs to the tumour-necrosis-factor-receptor superfamily and is expressed on the surface of most cell types (e.g., epithelial and myeloid lineages), but not on T or B cells. LTBR specifically binds the lymphotoxin membrane form (a complex of lymphotoxin-alpha and lymphtoxin-beta) and, with its ligand, plays a role in the development and organisation of lymphoid tissue and transformed cells. LTBR activation can trigger apoptosis; it associates with TRAF3, TRAF4 and TRAF5.
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For example, sST2 positively associated with TNFR1, LTBR, and GDF-15, but inversely associated with sVCAM, sICAM, and MCP-1.
Sc], scrapie prion protein; GPI, glycosylphosphatidylinositol; FTIR, Fourier transform infrared; NMR, nuclear magnetic resonance; FDA, Food and Drug Administration; EDRF, erythroid differentiation-related factor; and LTBR, lymphotoxin [beta]-receptor.
LTBR is a member of the TNF superfamily of cytokines.