Thus, we interpret this appearance of PIM as a variant of LSIL
that had originated from HPV-infected immature squamous metaplastic cells at or proximal to the squamocolumnar junction.
There were 46.15% (6/13) of samples with ASC-US, 57.14% (4/7) with ASC-H, 70.97% (22/31) with LSIL
, 80.36% (45/56) with HSIL, and 90.48% (19/21) with invasive squamous cell carcinoma (chi-square test = 10.7682, p = 0.029296, p < 0.05).
The performance of MGMT and C13ORF18 methylation combined with HR-HPV detection for triage of ASCUS and LSIL
is shown in [Table 5].
(27) reported 19.1 and 28.8% prevalence of HPV 56 among HPV+ women bearing NILM and LSIL
, not a single case was graded for p53 expression.
A total of 238 Pap smears were collected among the 75 women in this study group, of which 86% were negative or ASCUS and 13% were LSIL
. Only three Pap smears (1%) yielded a high-grade (HSIL) result.
Among all 854 abnormal findings (excluding normal colposcopy), 40.3% were diagnosed as normal/benign, 29.4% were diagnosed as LSIL
, 28.1% were diagnosed as HSIL, and 2.2% were diagnosed as cancerous.
One of these women had AG associated to a persistent infection with HR type 45, another presented LSIL
associated to mixed infections of HR types in both visits (18 plus 33 in the first test and 16 plus 18 in the second one) and the last one presented HSIL with a mixed infection of HR type 52 and 73 in the first visit and single infection with HR type 52 in the follow-up (Table 5).
Colposcopy and histology results were reported as per the Richart CIN system in which the terms atypical squamous cells of undetermined significance (ASCUS), quamous intraepithelial lesion (LSIL
, HSIL) are used.11-13
Kaunitz's summary of the findings of Huh and colleagues, (1) the population group included women with low-grade squamous intraepithelial lesions (LSIL
) or high-grade squamous intraepithelial lesions (HSIL) (ie, anything above atypical cells of undetermined significance [ASCUS]), along with women who tested positive for human papillomavirus (HPV) 16/18, regardless of cytology.
Atypical squamous cells of undetermined significance (ASCUS) and low-grade squamous intra-epithelial lesions (LSIL
) are minor lesions of the cervical epithelium, detectable by cytological examination of cells collected from the surface of the cervix of a woman.
La deteccion combinada de [p16.sup.INK4a]/Ki-67 parece ser un indicador altamente especifico de la existencia de celulas transformadas, que descaman de las lesiones premalignas y malignas de cuello uterino asociadas a VPHAR, sobre todo en pacientes con citologias atipicas, que incluyen a las atipias celulares de significado indeterminado (ASC-US) asi como a las atipias que no excluyen una lesion intraepitelial de alto grado (ASC-H) y a la lesion intraepitelial escamosa de bajo grado o LSIL
(11, 16, 18, 19).