KDM1A

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KDM1A

A gene on chromosome 1p36.12 that encodes a demethylase which acts on histone H3 as a coactivator or a co-repressor, depending on the context.
References in periodicals archive ?
The organizations will launch what they believe is the most comprehensive pre-clinical study to date, evaluating the effect of targeting LSD1 (lysine-specific histone demethylase 1A), a key enzyme that has increased expression in tumors of brain cancer patients.
The organizations will launch what they believe is the most comprehensive pre-clinical study to date, evaluating the effect of targeting LSD1, a key enzyme that has increased expression in tumors of brain cancer patients.
Treatment methods for glioblastoma have indicated no significant improvement for the last 15 years and the company serves to meet this unmet need through the development of allosteric modulators of an enzyme called LSD1. The compound developed by Beactica, BEA-17, recently showed indication of efficacy in an in vivo proof-of-principle study.
The understanding of the methylation regulation changed with the discovery of one histone demethylase, LSD1. Later, many enzymes regulating histone demethylation were discovered.
For example, Huang et al .[4] reported that lncRNA LINC00673 could be activated by SP1 and exerted its oncogenic properties through interacting with LSD1 and EZH2 in gastric cancer; Jin et al .[5] demonstrated that upregulation of lncRNA PlncRNA-1 promotes proliferation and induces epithelial-mesenchymal transition in prostate cancer; moreover, Li et al .[6] revealed that LINC00672 contributed p53-mediated gene suppression and promoted endometrial cancer chemosensitivity.
The funds from the agreement will be used to accelerate the pipeline development over the coming 12 months, including the advancement of Beactica's LSD1 programme through an in vivo proof-of-concept study in glioblastoma as well as studies in other indications.
Schule, "Lsd1 prevents age-programed loss of beige adipocytes," Proceedings of the National Acadamy of Sciences of the United States of America, vol.
Application of Cas9 fusions for epigenetic manipulation also includes the fusion of a histone demethylase LSD1 (Lys-specific histone demethylase) to Cas9 from Neisseria meningitides [64].
Guo et al., "Inhibition of LSD1 by pargyline inhibited process of EMT and delayed progression of prostate cancer in vivo," Biochemical and Biophysical Research Communications, vol.
Such upregulated lncRNA HOXA11-AS expression promotes tumor proliferation and invasion by scaffolding the chromatin modification factors PRC2, LSD1, and DNMT1 [16].
Yine mesane kanseri dokularinda normal dokulara gore histon modifikasyonlarindan olan EZH2 ve LSD1 ekspresyonunun anlamli derecede artmis oldugu bulunmus ancak bunun idrar orneklerindeki dogrulamasi yapilamamistir (41,42).
Sato et al., "Identification of myelin transcription factor 1 (MyT1) as a subunit of the neural cell type-specific lysine-specific demethylase 1 (LSD1) complex," The Journal of Biological Chemistry, vol.