KDM1A

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KDM1A

A gene on chromosome 1p36.12 that encodes a demethylase which acts on histone H3 as a coactivator or a co-repressor, depending on the context.
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Yine mesane kanseri dokularinda normal dokulara gore histon modifikasyonlarindan olan EZH2 ve LSD1 ekspresyonunun anlamli derecede artmis oldugu bulunmus ancak bunun idrar orneklerindeki dogrulamasi yapilamamistir (41,42).
Within my ERC-Consolidator project DISEASEAVATARS we discovered that increased GTF2I dosage represses key genes involved in intellectual disability, autism and neuronal function by associating with lysine demethylase 1 (LSD1), a key chromatin modifier, and found that LSD1 inhibition rescues GTF2I-dependent alterations.
Rasna Therapeutics is engaged in modulating the molecular targets LSD1 and NPM1, which are implicated in the disease progression of leukemia and lymphoma.
The authors found that lithium exerts its effect epigenetically via down-regulation of LSD1, a H3K4-specific histone demethylase.
The herpesvirus uses LSD1 to activate some of its own genes to infect a host and later to awaken from its dormant state in the host's sensory nerve cells.
Retinoic acid impairs estrogen signaling in breast cancer cells by interfering with activation of LSD1 via PKA.
Salarius is working on a highly selective LSD1 inhibitor.
They discovered that inhibiting an enzyme called LSD1, using TCP, could switch these genes on again and make the cancer cells susceptible to ATRA.
When LSD1 receives the signal that the stem cell is transitioning into a more differentiated state, the enzyme pops into action and silences the ESC genes' enhancers.
The lysine demethylase LSD1 (KDM1| is required for maintenance of global DNA methylation.
LSD1, a negative regulator of cell death, regulates SA induction of Cu,Zn-SOD (Kliebenstein et al.
Dietrich RA, Richberg MH, Schmidt R, Dean C, Dangl JL (1997) A novel zinc finger protein is encoded by the Arabidopsis LSD1 gene and functions as a negative regulator of plant cell death.