iPS cells have contributed enormously to understanding the biology of LQTS
, HCM, DCM and Noonan syndrome.
The current generation of the LQTS
mutation test gives positive result in 75% of the test and in less than 20% of SQTS cases (30).
Considering all above mentioned data and the fact the patient underwent a coronary angiography 4 months prior to current admission, that showed normal flow through the coronary arteries, thus ruling out an ischemic etiology, the hypothesis of a drug-induced long-QT syndrome (LQTS
) was raised
, patients with 2 pathogenic variants had longer corrected QT (QTc) intervals and were more likely to experience cardiac events and cardiac arrest than patients with single variants (25).
In practice, genetic testing in SUD has been shown to have substantial benefit in 1 study (1) in which 28% of asymptomatic first-degree relatives tested were found to have the LQTS
In the United States, the incidence of a genetic mutation that causes LQTS
is 1 in 2500 people.
Long QT syndrome (LQTS
) extends the relative refractory period of ventricular repolarization, thus placing the individual at risk for sudden cardiac death.
Long QT syndrome (LQTS
) is a disorder of myocardial conduction characterized by a prolonged QT interval seen on an electrocardiogram.
Now at fifteen years old, she convinces her parents to allow her to attend high school for a week, despite the threat that Long QT syndrome (LQTS
), a heart rhythm disorder, could kill her before the big football game on Friday night.
Subjects were excluded if; 1) had congenital long QT syndrome (LQTS
) 2)co-medicated with drugs that altered serum methadone level (eg rifampicin, carbamezapine, ketoconazole, phenytoin etc) 2) polysubtance abusers, 3) age less than 18, 4) addicted to opioid for less than 2 years, 5) known hypersensitivity to methadone, 6) abnormal liver functions and 7) acute medical or psychiatric disorders.
Thirty one (8.17%) out of 379 had definite diagnostic criteria for LQTS
according to Schwartz criteria and 17 (54.8%) of them were male and 14 (45.2%) were female.
In addition, the new report proposes major changes in the diagnostic criteria for the two most common primary arrhythmia syndromes: long QT syndrome (LQTS
) and Brugada syndrome.