KCNE2

(redirected from LQT6)

KCNE2

A gene on chromosome 21q22.12 that encodes a member of the voltage-gated, isk-related potassium channel subfamily; it is a small-membrane subunit, which assembles with the KCNH2 protein product, a pore-forming protein, and is expressed in heart and muscle.

Molecular pathology
KCNE2 mutations are associated with arrhythmias.
References in periodicals archive ?
Long QT and Jervelle Lange-Nielsen syndromes: Genetic defects and channel abnormalities Syndrome Gene Function Autosomal dominant LQT1 KCNQ1 [I.sub.ks] Decreased LQT2 KCNH2 [I.sub.Kr] Decreased LQT3 SCN5A [I.sub.Na] Decreased LQT4 ANK2 [I.sub.Na, K] Decreased LQT5 KCNE1 [I.sub.ks] Decreased LQT6 KCNE2 [I.sub.kr] Decreased LQT7 KCNJ2 [I.sub.k1] Decreased LQT8 CACNA1C [I.sub.Ca,L] Increased LQT9 CAV3 [I.sub.Na] Increased LQT10 SCN4B [I.sub.Na] Increased Autosomal recessive JLN1 KCNQ1 [I.sub.ks] Decreased JLN2 KCNE1 [I.sub.ks] Decreased Cardiac sodium ([I.sub.Na]), Potassium ([I.sub.ks], [I.sub.Kr], [I.sub.k1]) and Calcium currents
More recently, Abbott et al[30] identified MiRP1 as a [Beta]-subunit for HERG (see "LQT6: MiRP1").