KCNE1

(redirected from LQT5)

KCNE1

Notation for a voltage-gated potassium-channel gene.

KCNE1

A gene on chromosome 21q22.12 that encodes a member of the KCNE K+ channel family, which are essential to many cellular functions; they are protean in their electrophysiologic and pharmacologic properties. The KCNE1 protein product associates with the KVLQT1 protein product forming the delayed rectifier potassium channel.

Molecular pathology
KVLQT1 mutations are associated with Jervell and Lange-Nielsen and Romano-Ward forms of long-QT syndrome.
References in periodicals archive ?
V1763M LQT4 ANK2 Ankyrin-2 LQT5 KCNE1 Potassium voltage-gated channel subfamily E member 1 LQT6 KCNE2 Potassium voltage-gated channel subfamily E member 2 LQT7 KCNJ2 Inward rectifier potassium channel 2 LQT8 CACNA1 Voltage-dependent p.
Schott et al[27] mapped the fourth LQTS locus to chromosome 4q25-27 (LQT4), while a fifth gene (minK), located on chromosome 21q22,[28,29] was shown to be LQT5.