KCNQ1

(redirected from LQT)
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KCNQ1

A gene on chromosome 11p15.5 that encodes a voltage-gated potassium channel required for the repolarisation phase of the cardiac action potential. The KCNQ1 gene product can form heteromultimers with two other potassium channel proteins, KCNE1 and KCNE3.
 
Molecular pathology
KCNQ1 mutations are associated with hereditary long QT syndrome/Romano-Ward syndrome, Jervell and Lange-Nielsen syndrome and familial atrial fibrillation.
References in periodicals archive ?
Nowadays, beta blockers as well as implantable cardioverter-defibrillators or cardiostimulators are used to treat LQT syndrome.
were the first group to publish a hiPSC model for LQTS. Moretti and her coworkers used fibroblast-derived iPSCs from two asymptomatic patients (father and son) with a KCNQ1-G569A mutation and cells from healthy controls.
In USA, congenital LQTS accounts for 3000 to 4000 sudden deaths in children annually.
An NN was proposed as a vehicle for the capturing of LQT data in off-the-shelf control systems, providing a straightforward framework for implementation, as shown in Rieger and Naidu (2005).
The prevalence of LQTS is estimated to be 1 in 2,000-5,000; however, the expressivity, or penetrance, of the syndrome is highly variable even within the same family.
Long QT syndrome (LQTS) is a condition characterized by abnormal ventricular repolarization as a result of abnormal potassium or sodium cardiac ion channel currents.
T wave morphology was defined as in the congenital Long QT syndrome (LQTS): 1) "LQT1-like morphology" denoted a long QT interval (QTc interval [greater than or equal to] 450 ms) with broad T waves; 2) "LQT2-like morphology" denoted a long QT interval with double (notched) T waves; and 3) "LQT3-like morphology" denoted a long QT interval with small T waves separated from the (IRS interval by a long isoelectric ST-segment (12, 13).