Nowadays, beta blockers as well as implantable cardioverter-defibrillators or cardiostimulators are used to treat LQT
were the first group to publish a hiPSC model for LQTS
. Moretti and her coworkers used fibroblast-derived iPSCs from two asymptomatic patients (father and son) with a KCNQ1-G569A mutation and cells from healthy controls.
In USA, congenital LQTS
accounts for 3000 to 4000 sudden deaths in children annually.
An NN was proposed as a vehicle for the capturing of LQT
data in off-the-shelf control systems, providing a straightforward framework for implementation, as shown in Rieger and Naidu (2005).
The prevalence of LQTS
is estimated to be 1 in 2,000-5,000; however, the expressivity, or penetrance, of the syndrome is highly variable even within the same family.
Long QT syndrome (LQTS
) is a condition characterized by abnormal ventricular repolarization as a result of abnormal potassium or sodium cardiac ion channel currents.
T wave morphology was defined as in the congenital Long QT syndrome (LQTS
): 1) "LQT1-like morphology" denoted a long QT interval (QTc interval [greater than or equal to] 450 ms) with broad T waves; 2) "LQT2-like morphology" denoted a long QT interval with double (notched) T waves; and 3) "LQT3-like morphology" denoted a long QT interval with small T waves separated from the (IRS interval by a long isoelectric ST-segment (12, 13).