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LCP1A gene on chromosome 13q14.3 that encodes L-plastin/lymphocyte cytosolic protein 1, an actin-binding protein expressed only in haemopoietic cells. It plays a role in activating T-cells in response to co-stimulation with TCR/CD3 and CD2 or CD28. LCP1 modulates the cell surface expression of IL2RA/CD25 and CD69.
L-plastin has been found in many types of non-haemopoietic malignant cells, suggesting that its expression is linked to tumourigenesis in solid tissues.