LPIN1

LPIN1

A gene on chromosome 2p25.1 that encodes a magnesium-dependent phosphatidate phosphatase, which:
(1) Converts phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine synthesis in the endoplasmic reticulum;
(2) Is a nuclear transcriptional coactivator for PPARGC1A/PPARA, modulating lipid metabolism-related gene expression;
(3) Is involved in adipocyte differentiation; and which
(4) May be involved in mitochondrial fission, converting phosphatidic acid to diacylglycerol.

Molecular pathology
LPIN1 mutations may cause lipodystrophy.
References in periodicals archive ?
TG synthesis impairment was also associated with downregulation of two important enzymes of this pathway: 1-acyl-sn-glycerol-3-phosphate acyltransferase 2 (AGPAT2) and the phosphatidate phosphatase LPIN1 (lipin1) in BSCL2 knockdown during adipogenesis [11, 45].
The LGZG-treated NAFLD rats exhibited reduced expression of INSIG1 and LPIN1, which indicated the decreased cholesterol biosynthesis and triglyceride accumulation in the liver.
Many other SNPs of different genes involved in lipid metabolism, such as lipin 1 (LPIN1), oxidative stress, such as superoxide dismutase 2 (SOD2), and fibrogenesis, such as Kruppel-like factor 6 (KLF6), have been associated with the severity of liver damage in different studies on NAFLD patients [8-12].
Gomez et al., "Human subcutaneous adipose tissue LPIN1 expression in obesity, type 2 diabetes mellitus, and human immunodeficiency virus-associated lipodystrophy syndrome," Metabolism, vol.
These genes encoded cytokines (CSF3, CSF2, CCL3, TNF, CCR1, IL13, KIT, CCL5, CCL4, IL10, CXCL10, IL12RB2, IFNG, IL1B, IL1A, IL8, MET, CD40, HGF, LEP, CXCL16, CX3CR1, CCR2, PDGFRA, IL12B, IL2), lipid metabolism related genes (CD36, GPX4, LPIN1, LPL, LPB), transcription regulators (BCL3, FOS and NFKBIA), receptors (TNF, IL8, RELA, TLR1, TIRAP, TLR2, NFKBIA, NFKB1, TLR4, CD40, CCL5, CXCL10, FOS, JUN, MAP3K8, IL1B, LBP, IL12B, CD14, SPP1), and others such as SELP, SELL, and SOD1, all play a role in some aspect of the immune response including cytokine activity (IL10, TNF, IL8, and IL1B), cell adhesion (SELL and SELP), immune activation (CD14 and TLR2), acute phase reaction (TNF, IL1B, and SAA3), apoptosis (BCL2, BAX).
LPIN1 (lipin 1) and GAMT (guanidinoacetate N-methyltransferase) expression levels are subjected to p53-dependent increase [144, 145].
The upexpression of SREBF1 in goat mammary epithelial cells can increase DGAT1 and LPIN1, promoting the synthesis of fatty acids and the deposition of TAG [36].
Loor, "ACSL1, AGPAT6, FABP3, LPIN1, and SLC27A6 are the most abundant isoforms in bovine mammary tissue and their expression is affected by stage of lactation," The Journal of Nutrition, vol.
Gene Symbol Description FC DLAT Dihydrolipoamide -1,678 S-acetyltransferase HSPB7 Heat shock protein family B -1,422 (small) member 7 LPIN1 Lipin 1 -1,838 MECP2 Methyl-CpG binding protein 2 -1,22 NDUFS3 NADH: ubiquinone oxidoreductase -1,314 core subunit S3 NT5C 5', 3'-nucleotidase, cytosolic -1,524 SIRT5 Sirtuin 5 -1,255 YWHAQ Tyrosine 3-monooxygenase/tryptophan -1,364 5-monooxygenase activation protein theta
Interestingly, lipin 1 (LPIN1) was recognized to be the member of both downregulated transcription-regulating GO (regulation of transcription, DNA-dependent) and downregulated metabolic pathways.
The activation of PPAR[alpha] by Wy-14643 resulted in a general increase in lipid metabolism-related genes including several involved in lipid synthesis, such as lipin 1 (LPIN1) and sterol regulatory element binding transcription factor 1 (SREBF1) [28].