lysinuric protein intolerance

(redirected from LPI)
Also found in: Acronyms, Encyclopedia, Wikipedia.

ly·sin·ur·ic pro·tein in·tol·er·ance

[MIM*222700]
an autosomal recessive disorder characterized by elevated levels of dibasic amino acids (for example, l-lysine, l-arginine, and l-ornithine) in the urine; apparently due to a defect in dibasic amino acid transport.

lysinuric protein intolerance

An autosomal recessive disorder (OMIM:222700), more commonly seen in Finland and Italy, characterised by a defect in the plasma membrane transport of dibasic amino acids. On normal diets, these patients present with poor feeding, vomiting, diarrhoea, episodic hyperammonaemic coma and growth retardation, variably accompanied by hepatosplenomegaly, osteoporosis and life-threatening pulmonary alveolar proteinosis. 

Molecular pathology
Defects of SLC7A7, which encodes a protein involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids, cause lysinuric protein intolerance.
References in periodicals archive ?
The World Bank said that among lower middle-income economies, the Philippines was the fifth top performing in 2018 after Vietnam (ranked 39th with LPI score of 3.27), India (44th with score of 3.18), Indonesia (46th with score of 3.15) and Cote d'Ivoire (50th with score of 3.08).
Headquartered in New Berlin, Wisconsin, LPi has additional offices in Cleveland, Ohio, Hartford, Connecticut, Las Vegas, Nevada, Denver, Colorado, Winter Haven, Florida and Dublin, Ireland.
Through the application of best practices and 30 years of cross-industry experience, LPI has developed a team of loss prevention experts, servicing over 70 companies and 8,000 locations in the US and Canada.
With the issuance of new rules by the Consumer Financial Protection Bureau (CFPB) on LPI, which took effect on Jan.
In this section, we aim to obtain the optimal LPI performance for radar network architecture by judiciously designing the transmission power allocation among netted radars in the network.
LPI is providing us a phenomenal opportunity to reach cloud evangelists, influencers and consumers and helping us expand the community of Cloud subject matter experts by making our signature experiential hands-on training accessible to everyone.
The LPI and BDI methods produced concordant results in the present study, suggesting that both methods measure the same form of NBTI in plasma (r = 0.87).
Dr Emtir joined the LPI in 2003 as head of the Separation Technology Research Group (STRG) and has since done several research projects for Libya's downstream industries.
Genius G-Pen F350, G-Pen M712X, EasyPen M506, EasyPen M610X and MousePen i608X come with an USB interface, work area ranging from 3"x5" to 7.25"x12" and have a resolution varying from 2000 LPI to 4000 LPI.
The ratings reflect the support available from Lonpac's parent, LPI Capital Berhad (KUL:LPI), as well its ability to increase its market share while maintaining a favourable underwriting performance, despite the competitive operating environment in its core markets, namely Malaysia and Singapore, AM Best said.
(LPI), which operates as a wholly owned subsidiary of Indianbased Lupin Ltd., provides customers with a globally integrated team that focuses on delivering high-quality generics to the marketplace.
The three sub-indices of Land Price Index (LPI), namely Residential, Commercial and Industrial have contributed to this increase.