LPAR4 | definition of LPAR4 by Medical dictionary
LPAR4 A gene on chromosome Xq21.1 that encodes a lysophosphatidic acid receptor that may play a role in monocytic differentiation. LPAR4 may be related to the G-protein-coupled P2Y receptors, which bind purine and pyrimidine nucleotides.
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References in periodicals archive
Reconstitution of Lpar4
in mouse embryonic fibroblasts derived from [Lpar4.sup.-/-] mice reduces cell motility due to an LPA-induced decrease in Rac activation .
Ge et al., "Whole exome sequencing identifies lncRNA GAS8-AS1 and LPAR4
as novel papillary thyroid carcinoma driver alternations," Human Molecular Genetics, vol.
AA treatment was also verified to also target proliferative factors LPAR1, LPAR3, LPAR4
, LPAR5 and LPAR6.
On the other hand, LPAR4, LPAR5, and LPAR6 are expressed widely but at relatively low levels.
LPAR4 was also highly expressed in the cortex of the human ovary .