LPAR2A gene on chromosome 19p12 that encodes an endothelial differentiation, G protein-coupled (EDG) family receptor for lysophosphatidic acid (LPA), a bioactive lysophospholipid that mediates diverse biologic functions, including proliferation, platelet aggregation, smooth
muscle contraction, inhibition of neuroblastoma cell differentiation, chemotaxis and tumour cell invasion. LPAR2 contributes to Ca2+ mobilisation, a critical cellular response to LPA in cells, by association with Gi and Gq proteins.
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