LPAR2

LPAR2

A gene on chromosome 19p12 that encodes an endothelial differentiation, G protein-coupled (EDG) family receptor for lysophosphatidic acid (LPA), a bioactive lysophospholipid that mediates diverse biologic functions, including proliferation, platelet aggregation, smooth
muscle contraction, inhibition of neuroblastoma cell differentiation, chemotaxis and tumour cell invasion. LPAR2 contributes to Ca2+ mobilisation, a critical cellular response to LPA in cells, by association with Gi and Gq proteins.
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References in periodicals archive ?
Antibody against LPAR1 was purchased from Cayman Chemical (Ann Arbor, MI); antibodies for LPAR2 and LPAR3 were from LifeSpan BioScience (Seattle, WA).
PCR primers were designed for human LPAR1, LPAR2, and LPAR3 for regular PCR.
For example, LPAR1 is highly expressed in the nervous system [32], LPAR2 in immune organs such as the thymus and spleen [33], and LPAR3 in reproductive organs such as the ovary and uterus [7, 16, 34, 35].
[44] demonstrated mRNA expression of three LPA receptors, LPAR1, LPAR2, and LPAR3, in the granulosa-lutein cells from women undergoing in vitro fertilization.
[56] detected high levels of LPAR2 and LPAR3 gene expression in the placentas of patients with gestational hypertension and preeclampsia.
[67] suggested the involvement of the upregulation of LPAR2, but not LPAR1 or LPAR3, in the mammary gland carcinoma pathogenesis in the breast cancer of postmenopausal women.
[76] proved that LPAR2 and LPAR3 were upregulated in ovarian cancer tissues.