LPAR3

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LPAR3

A gene on chromosome 19p12 that encodes an endothelial differentiation, G protein-coupled (EDG) family receptor for lysophosphatidic acid, a bioactive lysophospholipid that mediates diverse biologic functions, including proliferation, platelet aggregation, smooth
muscle contraction, inhibition of neuroblastoma cell differentiation, chemotaxis and tumour cell invasion, by Ca2+ mobilisation.
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References in periodicals archive ?
LPA3 receptor (EDG-7) contains 3 exons, has 353 amino acids, and a 40kDa-estimated mass [37, 38].
In rat lung adenocarcinoma, loss of LPA3 due to methylation of the promoter enhances tumor progression by increasing invasion, suggesting a protective role of [LPA.sub.3] in this neoplasia [66].
LPA can upregulate miR-23a expression by activation of LPA3 dependent PI3K/Akt pathway [36].
En cuanto a las variables de control, la variable edad muestra que por un ano adicional en la edad del artesano aumenta en un 0,05% la probabilidad de dedicarse a la elaboracion de bienes que se enmarcan dentro de la linea de produccion artesanal de los sombreros y bisuteria en paja toquilla; la misma variable en la LPA3 no resulto estadisticamente significativa.
Variable Obs Media Estandar Min Max Marroquineria 281 0,2455516 0,4311817 0 1 (LPA1) Sombreros (LPA2) 281 0,0818505 0,274626 0 1 Barniz (LPA3) 281 0,0604982 0,238833 0 1 Tienepareja 281 0,6405694 0,4806896 0 1 Jefedehogar 281 0,772242 0,4201339 0 1 Mujercabezah 281 0,3345196 0,472664 0 1 Lugardewtaller 281 0,4412811 0,497426 0 1 Pasto 281 0,6868327 0,4646092 0 1 Ingreso 281 $ 963.452 $ 1.951.389 $ 20.000 $ 20.000.000 Edadjefe 281 45,78648 11,66821 21 82 Personasporhogar 281 3,758007 1,737758 1 12 Fuente: calculos propios con base en el estudio SCIMAN, 2013.
A number of components of the prostaglandin synthesis system-cyclooxygenase-2 (COX-2), secretory phospholipase A2 group: IIA, V, and IB (sPLA2-IIA, sPLA2-V, sPLA2-IB), glypican-1, PG-E synthase, PG-E receptors, and lysophosphatidic acid receptor 3 (LPA3) have been estimated and very low levels of sPLA2-IIA and COX-2 were measured in 85% of RIF patients.
Dioctylglycerol pyrophosphate (DGPP) is a selective antagonist of lysophosphatidic acid (LPA) receptor LPA3. Although LPA2 shares a high degree of sequence homology with LPA3, DGPP is not an antagonist for LPA2.
(a and b), LPA1, LPA2, and LPA3 mRNA and protein are all expressed in HeLa cells, as indicated by PCR and Western blot, respectively.
Although they have a high degree of sequence homology, the lysophosphatidic acid (LPA) receptor LPA3, but not LPA2, binds the LPA-receptor antagonist dioctanoyl glycerol phosphate (DGPP).
Lu, "Cyclic regulation of LPA3 in human endometrium," Archives of Gynecology and Obstetrics, vol.
Catt, "Roles of LPA3 and COX-2 in implantation," Trends in Endocrinology & Metabolism, vol.