LPAR2

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LPAR2

A gene on chromosome 19p12 that encodes an endothelial differentiation, G protein-coupled (EDG) family receptor for lysophosphatidic acid (LPA), a bioactive lysophospholipid that mediates diverse biologic functions, including proliferation, platelet aggregation, smooth
muscle contraction, inhibition of neuroblastoma cell differentiation, chemotaxis and tumour cell invasion. LPAR2 contributes to Ca2+ mobilisation, a critical cellular response to LPA in cells, by association with Gi and Gq proteins.
References in periodicals archive ?
68) These results, together with the finding that LPA activates Rho-ROCK-myosin II pathways via LPA2 in T cells, suggest that the LPA generated by FRCs acts locally on T cells via LPA2, thereby regulating T cell contractility and motility in the lymph node reticular network (68) (Fig.
En efecto, en la Tabla 6 se observa que, en terminos de la variable jefe de hogar, la probabilidad de pertenecer a la linea de produccion LPA1 y/o LPA2 disminuye, en comparacion con aquellos que no son jefes de hogar.
This signaling pathway involves lysophosphatidic acid (LPA) acting via presynaptic LPA2 receptors.
To investigate how LPA exerted this effect, the team produced mice that genetically lack one or both of the two receptors -- LPA1 and LPA2 -- to which LPA can bind on ventricle-building fetal progenitor cells, finding that the LPA1 receptor was required to produce hydrocephalus.
The ICM system expands MP Filtri's hydraulic particle counter family, which also features the PML2 and LPA2 series.
69) The G protein-coupled receptors for lysophosphatidic acid, LPA1 and LPA2, which can signal through nuclear factor [kappa]B or Akt, were recently shown by Yamada et al (70) to be expressed in MPM cell lines and human samples, and the addition of LPA enhanced cell proliferation and motility via LPA1 and LPA2, respectively.
2 601965 No definido EDG4 LPA2 19d12 605110 No definido EDG5 S1P2 19q13 605111 No definido EDG6 S1P4 19p13.
Although LPA2 shares a high degree of sequence homology with LPA3, DGPP is not an antagonist for LPA2.
Site-directed mutagenesis was performed on LPA2 and LPA3 to mutate residues predicted to be critical for binding to DGPP.