(68) These results, together with the finding that LPA activates Rho-ROCK-myosin II pathways via LPA2
in T cells, suggest that the LPA generated by FRCs acts locally on T cells via LPA2
, thereby regulating T cell contractility and motility in the lymph node reticular network (68) (Fig.
En efecto, en la Tabla 6 se observa que, en terminos de la variable jefe de hogar, la probabilidad de pertenecer a la linea de produccion LPA1 y/o LPA2
disminuye, en comparacion con aquellos que no son jefes de hogar.
In addition to CD27, Siva-1 can interact with the peroxisomal membrane protein (PMP22) (4), tyrosine kinase 2 (Tyk2) (5), pyrin (6), lysophosphatidic acid receptor 2 (LPA2
) (7), the CVB3 capsid protein VP2 (8), and CD4 (9).
To investigate how LPA exerted this effect, the team produced mice that genetically lack one or both of the two receptors -- LPA1 and LPA2
-- to which LPA can bind on ventricle-building fetal progenitor cells, finding that the LPA1 receptor was required to produce hydrocephalus.
The ICM system expands MP Filtri's hydraulic particle counter family, which also features the PML2 and LPA2
(69) The G protein-coupled receptors for lysophosphatidic acid, LPA1 and LPA2
, which can signal through nuclear factor [kappa]B or Akt, were recently shown by Yamada et al (70) to be expressed in MPM cell lines and human samples, and the addition of LPA enhanced cell proliferation and motility via LPA1 and LPA2
shares a high degree of sequence homology with LPA3, DGPP is not an antagonist for LPA2
knockout mice are mostly normal, suggesting a possible functional redundancy in relation to LPAr A [Lpar1.sup.-/-] and [Lpar2.sup.-/-] model has also been evaluated .
Although they have a high degree of sequence homology, the lysophosphatidic acid (LPA) receptor LPA3, but not LPA2
, binds the LPA-receptor antagonist dioctanoyl glycerol phosphate (DGPP).
(a and b), LPA1, LPA2
, and LPA3 mRNA and protein are all expressed in HeLa cells, as indicated by PCR and Western blot, respectively.